Paula L. Croal
Field strength dependence of grey matter R2* on venous oxygenation
Croal, Paula L.; Driver, Ian D.; Francis, Susan T.; Gowland, Penny A.
Ian D. Driver
Professor SUSAN FRANCIS firstname.lastname@example.org
Professor of Physics
Professor PENNY GOWLAND email@example.com
Professor of Physics
The relationship between venous blood oxygenation and change in transverse relaxation rate (ΔR2 *) plays a key role in calibrated BOLD fMRI. This relationship, defined by the parameter β, has previously been determined using theoretical simulations and experimental measures. However, these earlier studies have been confounded by the change in venous cerebral blood volume (CBV) in response to functional tasks. This study used a double-echo gradient echo EPI scheme in conjunction with a graded isocapnic hyperoxic sequence to assess quantitatively the relationship between the fractional venous blood oxygenation (1-Yv) and transverse relaxation rate of grey matter (ΔR2 * GM), without inducing a change in vCBV.
The results demonstrate that the relationship between ΔR2 * and fractional venous oxygenation at all magnet field strengths studied was adequately described by a linear relationship. The gradient of this relationship did not increase monotonically with field strength, which may be attributed to the relative contributions of intravascular and extravascular signals which will vary with both field strength and blood oxygenation.
Croal, P. L., Driver, I. D., Francis, S. T., & Gowland, P. A. (2017). Field strength dependence of grey matter R2* on venous oxygenation. NeuroImage, 146, 327-332. https://doi.org/10.1016/j.neuroimage.2016.10.004
|Journal Article Type||Article|
|Acceptance Date||Oct 1, 2016|
|Online Publication Date||Oct 5, 2016|
|Deposit Date||Oct 17, 2016|
|Publicly Available Date||Oct 17, 2016|
|Peer Reviewed||Peer Reviewed|
|Keywords||calibrated BOLD; fMRI; R2⁎ quantification; oxygenation;
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
You might also like
Multiparametric measurement of cerebral physiology using calibrated fMRI
The effect of isocapnic hyperoxia on neurophysiology as measured with MRI and MEG
In silico evaluation and optimisation of magnetic resonance elastography of the liver