The Human Connectome Project's neuroimaging approach

Glasser, Matthew F.; Smith, Stephen M.; Marcus, Daniel S.; Andersson, Jesper L.R.; Auerbach, Edward J.; Behrens, Timothy E.J.; Coalson, Timothy S.; Harms, Michael P.; Jenkinson, Mark; Moeller, Steen; Robinson, Emma C.; Sotiropoulos, Stamatios N.; Xu, Junqian; Yacoub, Essa; Ugurbil, Kamil; Van Essen, David C.

Abstract

Noninvasive human neuroimaging has yielded many discoveries about the brain. Numerous methodological advances have also occurred, though inertia has slowed their adoption. This paper presents an integrated approach to data acquisition, analysis and sharing that builds upon recent advances, particularly from the Human Connectome Project (HCP). The 'HCP-style' paradigm has seven core tenets: (i) collect multimodal imaging data from many subjects; (ii) acquire data at high spatial and temporal resolution; (iii) preprocess data to minimize distortions, blurring and temporal artifacts; (iv) represent data using the natural geometry of cortical and subcortical structures; (v) accurately align corresponding brain areas across subjects and studies; (vi) analyze data using neurobiologically accurate brain parcellations; and (vii) share published data via user-friendly databases. We illustrate the HCP-style paradigm using existing HCP data sets and provide guidance for future research. Widespread adoption of this paradigm should accelerate progress in understanding the brain in health and disease.

Citation

Glasser, M. F., Smith, S. M., Marcus, D. S., Andersson, J. L., Auerbach, E. J., Behrens, T. E., Coalson, T. S., Harms, M. P., Jenkinson, M., Moeller, S., Robinson, E. C., Sotiropoulos, S. N., Xu, J., Yacoub, E., Ugurbil, K., & Van Essen, D. C. (2016). The Human Connectome Project's neuroimaging approach. Nature Neuroscience, 19(9), https://doi.org/10.1038/nn.4361

• Journal Article Type: Article
• Acceptance Date: Jul 18, 2016
• Publication Date: Aug 26, 2016
• Deposit Date: Apr 5, 2018
• Publicly Available Date: Apr 5, 2018
• Journal: Nature Neuroscience
• Print ISSN: 1097-6256
• Electronic ISSN: 1546-1726
• Publisher: Nature Publishing Group
• Peer Reviewed: Peer Reviewed
• Volume: 19
• Issue: 9
• DOI: https://doi.org/10.1038/nn.4361
• Keywords: Language; Neural circuits; Sensory processing
• Public URL: https://nottingham-repository.worktribe.com/output/804345
• Publisher URL: https://www.nature.com/articles/nn.4361
• Contract Date: Apr 5, 2018