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ABCA7 p.G215S as potential protective factor for Alzheimer’s disease

Sassi, C.; Nalls, M.A.; Ridge, P.G.; Gibbs, R.; Ding, J.; Lupton, M.K.; Troakes, C.; Lunnon, K.; Al-Sarraj, S.; Brown, K.S.; Medway, C.; Clement, Naomi; Lord, J.; Turton, James; Bras, J.; Almeida, M.R.; ARUK, Consortium

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Authors

C. Sassi

M.A. Nalls

P.G. Ridge

R. Gibbs

J. Ding

M.K. Lupton

C. Troakes

K. Lunnon

S. Al-Sarraj

K.S. Brown

C. Medway

Naomi Clement

J. Lord

James Turton

J. Bras

M.R. Almeida

Consortium ARUK



Abstract

Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over 20 susceptibility loci for Alzheimer’s disease (AD).
Despite the evidence showing the contribution of these loci to AD pathogenesis, their genetic architecture has not been extensively investigated, leaving the possibility that low frequency and rare coding variants may also occur and contribute to the risk of disease. We have used exome and genome sequencing data to analyse the single independent and joint effect of rare and low frequency protein coding variants in 9 AD GWAS loci with the strongest effect sizes after APOE (BIN1, CLU, CR1, PICALM, MS4A6A, ABCA7, EPHA1, CD33, CD2AP) in a cohort of 332 sporadic AD cases and 676 elderly controls of British and North American ancestry. We identified coding variability in ABCA7 as contributing to AD risk. This locus harbors a low frequency coding variant (p.G215S, rs72973581, MAF=4.3%) conferring a modest but statistically significant protection against AD (p-value= 6x10-4, OR=0.57, 95% CI 0.41-0.80). Notably, our results are not driven by an enrichment of loss of function variants in ABCA7, recently reported as main pathogenic factor underlying AD risk at this locus. In summary, our study confirms the role of ABCA7 in AD and provide new insights that should address functional studies.

Journal Article Type Article
Acceptance Date Apr 10, 2016
Online Publication Date Apr 20, 2016
Publication Date Oct 31, 2016
Deposit Date May 17, 2016
Publicly Available Date May 17, 2016
Journal Neurobiology of Aging
Print ISSN 0197-4580
Electronic ISSN 1558-1497
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 46
Pages 235.e1-235.e9
DOI https://doi.org/10.1016/j.neurobiolaging.2016.04.004
Public URL https://nottingham-repository.worktribe.com/output/784471
Publisher URL http://www.sciencedirect.com/science/article/pii/S0197458016300318

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