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Characterisation of human saliva as a platform for oral dissolution medium development

Gittings, Sally; Turnbull, Neil; Henry, Brian; Roberts, Clive J.; Gershkovich, Pavel

Authors

Sally Gittings

Neil Turnbull

Brian Henry



Abstract

Human saliva is a biological fluid of great importance in the field of dissolution testing. However, until now, no consensus has been reached on its key characteristics relevant to dissolution testing. As a result, it is difficult to select or develop an in vitro dissolution medium to best represent human saliva. In this study, the pH, buffer capacity, surface tension, viscosity and flow rate of both unstimulated (US) and stimulated (SS) human saliva were investigated in order to provide a platform of reference for future dissolution studies using simulated salivary fluids. Age and gender related differences in a sample size of 30 participants for each parameter were investigated. Significant differences were established between US and SS for all characteristics except surface tension. Therefore, the requirement for using two simulated salivary fluids should be considered when developing an oral dissolution model.

Journal Article Type Article
Publication Date 2015-04
Journal European Journal of Pharmaceutics and Biopharmaceutics
Print ISSN 0939-6411
Electronic ISSN 0939-6411
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 91
Pages 16-24
APA6 Citation Gittings, S., Turnbull, N., Henry, B., Roberts, C. J., & Gershkovich, P. (2015). Characterisation of human saliva as a platform for oral dissolution medium development. European Journal of Pharmaceutics and Biopharmaceutics, 91, 16-24. https://doi.org/10.1016/j.ejpb.2015.01.007
DOI https://doi.org/10.1016/j.ejpb.2015.01.007
Keywords Human saliva; Taste masking; Dissolution; Biorelevant medium; Physicochemical characteristics; Oral cavity
Publisher URL http://www.sciencedirect.com/science/article/pii/S0939641115000107
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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