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Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy

Rawling, M.J.; Storr, T.E.; Bawazir, W.A.; Cully, S.J.; Lewis, W.; Makki, M.S.I.T.; Strutt, I.R.; Jones, G.; Hamza, D.; Stockman, R.A.

Authors

M.J. Rawling

T.E. Storr

W.A. Bawazir

S.J. Cully

W. Lewis

M.S.I.T. Makki

I.R. Strutt

G. Jones

D. Hamza



Abstract

A heterocyclic, sp3-rich chemical scaffold was synthesised in just 6 steps via a highly regio- and diastereo-selective tandem nitrone formation/intramolecular nitrone–alkene [3+2] cycloaddition reaction. A library of 543 lead-like compounds based on the scaffold core has been produced.

Journal Article Type Article
Publication Date Jul 9, 2015
Journal Chemical Communications
Print ISSN 1359-7345
Electronic ISSN 1364-548X
Publisher Royal Society of Chemistry
Peer Reviewed Peer Reviewed
Volume 51
Issue 64
APA6 Citation Rawling, M., Storr, T., Bawazir, W., Cully, S., Lewis, W., Makki, M., …Stockman, R. (2015). Facile access to a heterocyclic, sp3-rich chemical scaffold via a tandem condensation/intramolecular nitrone–alkene [3+2] cycloaddition strategy. Chemical Communications, 51(64), https://doi.org/10.1039/c5cc05070g
DOI https://doi.org/10.1039/c5cc05070g
Publisher URL http://pubs.rsc.org/en/Content/ArticleLanding/2015/CC/C5CC05070G#!divAbstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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