Skip to main content

Research Repository

Advanced Search

Expression of myogenic regulatory factors in chicken embryos during somite and limb development

Mok, Gi Fay; Mohammed, Rabeea Hazim; Sweetman, Dylan

Authors

Gi Fay Mok

Rabeea Hazim Mohammed

Dylan Sweetman dylan.sweetman@nottingham.ac.uk



Abstract

The expression of the myogenic regulatory factors (MRFs), Myf5, MyoD, myogenin (Mgn) and MRF4 have been analysed during the development of chicken embryo somites and limbs. In somites, Myf5 is expressed first in somites and paraxial mesoderm at HH stage 9 followed by MyoD at HH stage 12, and Mgn and MRF4 at HH stage 14. In older somites, Myf5 and MyoD are also expressed in the ventrally extending myotome prior to Mgn and MRF4 expression. In limb muscles a similar temporal sequence is observed with Myf5 expression detected first in forelimbs at HH stage 22, MyoD at HH stage 23, Mgn at HH stage 24 and MRF4 at HH stage 30. This report describes the precise time of onset of expression of each MRF in somites and limbs during chicken embryo development, and provides a detailed comparative timeline of MRF expression in different embryonic muscle groups.

Journal Article Type Article
Publication Date Jul 16, 2015
Journal Journal of Anatomy
Print ISSN 0021-8782
Electronic ISSN 1469-7580
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 227
Issue 3
APA6 Citation Mok, G. F., Mohammed, R. H., & Sweetman, D. (2015). Expression of myogenic regulatory factors in chicken embryos during somite and limb development. Journal of Anatomy, 227(3), doi:10.1111/joa.12340
DOI https://doi.org/10.1111/joa.12340
Keywords Chicken embryo, MRF, MRF4, Myf5, MyoD, Myogenesis, Myogenin
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/joa.12340/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

Files

Mok_et_al-2015-Journal_of_Anatomy.pdf (2.2 Mb)
PDF

Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





Downloadable Citations

;