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Differential modulation of the N2 and P3 event-related potentials by response conflict and inhibition

Groom, Madeleine J.; Cragg, Lucy

Authors

LUCY CRAGG lucy.cragg@nottingham.ac.uk
Associate Professor



Abstract

Background: Developing reliable and specific neural markers of cognitive processes is essential to improve understanding of healthy and atypical brain function. Despite extensive research there remains uncertainty as to whether two electrophysiological markers of cognitive control, the N2 and P3, are better conceptualised as markers of response inhibition or response conflict. The present study aimed to directly compare the effects of response inhibition and response conflict on the N2 and P3 event-related potentials, within-subjects.
Method: A novel hybrid go/no-go flanker task was performed by 19 healthy adults aged 18 to 25 years while EEG data were collected. The response congruence of a central target stimulus and 4 flanking stimuli was manipulated between trials to vary the degree of response conflict. Response inhibition was required on a proportion of trials. N2 amplitude was measured at two frontal electrode sites; P3 amplitude was measured at 4 midline electrode sites.
Results: N2 amplitude was greater on incongruent than congruent trials but was not enhanced by response inhibition when the stimulus array was congruent. P3 amplitude was greater on trials requiring response inhibition; this effect was more pronounced at frontal electrodes. P3 amplitude was also enhanced on incongruent compared with congruent trials.
Discussion: The findings support a role for N2 amplitude as a marker of response conflict and for the frontal shift of the P3 as a marker of response inhibition. This paradigm could be applied to clinical groups to help clarify the precise nature of impaired action control in disorders such as attention deficit/hyperactivity disorders (ADHD).

Journal Article Type Article
Publication Date Jul 31, 2015
Journal Brain and Cognition
Print ISSN 0278-2626
Electronic ISSN 1090-2147
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 97
APA6 Citation Groom, M. J., & Cragg, L. (2015). Differential modulation of the N2 and P3 event-related potentials by response conflict and inhibition. Brain and Cognition, 97, doi:10.1016/j.bandc.2015.04.004
DOI https://doi.org/10.1016/j.bandc.2015.04.004
Keywords Event-related potentials; N2; P3; response inhibition; response conflict; attention deficit/hyperactivity disorder
Publisher URL http://www.sciencedirect.com/science/article/pii/S027826261500038X
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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