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Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population

Vukicevic, Vladimir; Rubin de Celis, Maria Fernandez; Pellegata, Natalia S.; Bornstein, Stefan R.; Androutsellis-Theotokis, Andreas; Ehrhart-Bornstein, Monika


Vladimir Vukicevic

Maria Fernandez Rubin de Celis

Natalia S. Pellegata

Stefan R. Bornstein

Andreas Androutsellis-Theotokis

Monika Ehrhart-Bornstein


The adrenal is a highly plastic organ with the ability to adjust to physiological needs by adapting hormone production but also by generating and regenerating both adrenocortical and adrenomedullary tissue. It is now apparent that many adult tissues maintain stem and progenitor cells that contribute to their maintenance and adaptation. Research from the last years has proven the existence of stem and progenitor cells also in the adult adrenal medulla throughout life. These cells maintain some neural crest properties and have the potential to differentiate to the endocrine and neural lineages. In this article, we discuss the evidence for the existence of adrenomedullary multi potent progenitor cells, their isolation and characterization, their differentiation potential as well as their clinical potential in transplantation therapies but also in pathophysiology.


Vukicevic, V., Rubin de Celis, M. F., Pellegata, N. S., Bornstein, S. R., Androutsellis-Theotokis, A., & Ehrhart-Bornstein, M. (2015). Adrenomedullary progenitor cells: isolation and characterization of a multi-potent progenitor cell population. Molecular and Cellular Endocrinology, 408,

Journal Article Type Article
Acceptance Date Dec 27, 2014
Online Publication Date Jan 6, 2015
Publication Date Jun 15, 2015
Deposit Date May 12, 2017
Journal Molecular and Cellular Endocrinology
Print ISSN 0303-7207
Electronic ISSN 1872-8057
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 408
Keywords Adrenal medulla; Sympathoadrenal; Stem cells; Progenitor cells; ALDH; Hes3
Public URL
Publisher URL
Additional Information AAM needed. No response from requester. If supplied, set to CCANCND. Author not member of university at time of publication.