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Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study

Hayward, Andrew C.; Wang, Lili; Goonetilleke, Nilu; Fragaszy, Ellen B.; Bermingham, Alison; Copas, Andrew; Dukes, Oliver; Millett, Elizabeth R.C.; Nazareth, Irwin; Nguyen-Van-Tam, Jonathan S.; Watson, John M.; Zambon, Maria; Johnson, Anne M.; McMichael, Andrew J.

Authors

Andrew C. Hayward

Lili Wang

Nilu Goonetilleke

Ellen B. Fragaszy

Alison Bermingham

Andrew Copas

Oliver Dukes

Elizabeth R.C. Millett

Irwin Nazareth

John M. Watson

Maria Zambon

Anne M. Johnson

Andrew J. McMichael



Abstract

Rationale: A high proportion of influenza infections are asymptomatic. Animal and human challenge studies and observational studies suggest T cells protect against disease among those infected, but the impact of T-cell immunity at the population level is unknown.

Objectives: To investigate whether naturally preexisting T-cell responses targeting highly conserved internal influenza proteins could provide cross-protective immunity against pandemic and seasonal influenza.

Methods: We quantified influenza A(H3N2) virus–specific T cells in a population cohort during seasonal and pandemic periods between 2006 and 2010. Follow-up included paired serology, symptom reporting, and polymerase chain reaction (PCR) investigation of symptomatic cases.

Measurements and Main Results: A total of 1,414 unvaccinated individuals had baseline T-cell measurements (1,703 participant observation sets). T-cell responses to A(H3N2) virus nucleoprotein (NP) dominated and strongly cross-reacted with A(H1N1)pdm09 NP (P 

Journal Article Type Article
Publication Date Jun 15, 2015
Journal American Journal of Respiratory and Critical Care Medicine
Print ISSN 1073-449X
Electronic ISSN 1535-4970
Publisher American Thoracic Society
Peer Reviewed Peer Reviewed
Volume 191
Issue 12
Pages 1422-1431
APA6 Citation Hayward, A. C., Wang, L., Goonetilleke, N., Fragaszy, E. B., Bermingham, A., Copas, A., …McMichael, A. J. (2015). Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study. American Journal of Respiratory and Critical Care Medicine, 191(12), 1422-1431. https://doi.org/10.1164/rccm.201411-1988oc
DOI https://doi.org/10.1164/rccm.201411-1988oc
Keywords cellular immunity; T lymphocytes; cohort studies
Publisher URL http://www.atsjournals.org/doi/10.1164/rccm.201411-1988OC
Related Public URLs http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476562/
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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R2_Tcell_AJRCCM_manuscript (unmarked).pdf (519 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf


R2_Tcell_AJRCCM_supplement.pdf (325 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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