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Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study

Hayward, Andrew C.; Wang, Lili; Goonetilleke, Nilu; Fragaszy, Ellen B.; Bermingham, Alison; Copas, Andrew; Dukes, Oliver; Millett, Elizabeth R.C.; Nazareth, Irwin; Nguyen-Van-Tam, Jonathan S.; Watson, John M.; Zambon, Maria; Johnson, Anne M.; McMichael, Andrew J.

Authors

Andrew C. Hayward

Lili Wang

Nilu Goonetilleke

Ellen B. Fragaszy

Alison Bermingham

Andrew Copas

Oliver Dukes

Elizabeth R.C. Millett

Irwin Nazareth

Jonathan S. Nguyen-Van-Tam jvt@nottingham.ac.uk

John M. Watson

Maria Zambon

Anne M. Johnson

Andrew J. McMichael



Abstract

Rationale: A high proportion of influenza infections are asymptomatic. Animal and human challenge studies and observational studies suggest T cells protect against disease among those infected, but the impact of T-cell immunity at the population level is unknown.

Objectives: To investigate whether naturally preexisting T-cell responses targeting highly conserved internal influenza proteins could provide cross-protective immunity against pandemic and seasonal influenza.

Methods: We quantified influenza A(H3N2) virus–specific T cells in a population cohort during seasonal and pandemic periods between 2006 and 2010. Follow-up included paired serology, symptom reporting, and polymerase chain reaction (PCR) investigation of symptomatic cases.

Measurements and Main Results: A total of 1,414 unvaccinated individuals had baseline T-cell measurements (1,703 participant observation sets). T-cell responses to A(H3N2) virus nucleoprotein (NP) dominated and strongly cross-reacted with A(H1N1)pdm09 NP (P 

Journal Article Type Article
Publication Date Jun 15, 2015
Journal American Journal of Respiratory and Critical Care Medicine
Print ISSN 1073-449X
Electronic ISSN 1535-4970
Publisher American Thoracic Society
Peer Reviewed Peer Reviewed
Volume 191
Issue 12
Pages 1422-1431
APA6 Citation Millett, E. R. C., Hayward, A. C., Wang, L., Goonetilleke, N., Fragaszy, E. B., Bermingham, A., …McMichael, A. J. (2015). Natural T Cell–mediated Protection against Seasonal and Pandemic Influenza. Results of the Flu Watch Cohort Study. American Journal of Respiratory and Critical Care Medicine, 191(12), 1422-1431. https://doi.org/10.1164/rccm.201411-1988oc
DOI https://doi.org/10.1164/rccm.201411-1988oc
Keywords cellular immunity; T lymphocytes; cohort studies
Publisher URL http://www.atsjournals.org/doi/10.1164/rccm.201411-1988OC
Related Public URLs http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4476562/
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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R2_Tcell_AJRCCM_manuscript (unmarked).pdf (519 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf


R2_Tcell_AJRCCM_supplement.pdf (325 Kb)
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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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