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Transcriptional regulation and responses in filamentous fungi exposed to lignocellulose

Daly, Paul; van Munster, Jolanda M.; Archer, David B.; Raulo, Roxane

Authors

Paul Daly

Jolanda M. van Munster

David B. Archer

Roxane Raulo



Contributors

Roberto Nascimento Silva
Editor

Abstract

Biofuels derived from lignocellulose are attractive alternative fuels but their production suffers from a costly and inefficient saccharification step that uses fungal enzymes. One route to improve this efficiency is to understand better the transcriptional regulation and responses of filamentous fungi to lignocellulose. Sensing and initial contact of the fungus with lignocellulose is an important aspect. Differences and similarities in the responses of fungi to different lignocellulosic substrates can partly be explained with existing understanding of several key regulators and their mode of action, as will be demonstrated for Trichoderma reesei, Neurospora crassa and Aspergillus spp. The regulation of genes encoding Carbohydrate Active enZymes (CAZymes) is influenced by the presence of carbohydrate monomers and short oligosaccharides, as well as the external stimuli of pH and light. We explore several important aspects of the response to lignocellulose that are not related to genes encoding CAZymes, namely the regulation of transporters, accessory proteins and stress responses. The regulation of gene expression is examined from the perspective of mixed cultures and models are presented for the nature of the transcriptional basis for any beneficial effects of such mixed cultures. Various applications in biofuel technology are based on manipulating transcriptional regulation and learning from fungal responses to lignocelluloses. Here we critically access the application of fungal transcriptional responses to industrial saccharification reactions. As part of this chapter, selected regulatory mechanisms are also explored in more detail.

Citation

Daly, P., van Munster, J. M., Archer, D. B., & Raulo, R. (2015). Transcriptional regulation and responses in filamentous fungi exposed to lignocellulose. In R. N. Silva (Ed.), Mycology: current and future developments: fungal biotechnology for biofuel production. Bentham Science. https://doi.org/10.2174/97816810807411150101

Acceptance Date Jan 1, 2015
Publication Date Jul 1, 2015
Deposit Date Apr 27, 2017
Publicly Available Date Apr 27, 2017
Peer Reviewed Peer Reviewed
Book Title Mycology: current and future developments: fungal biotechnology for biofuel production
ISBN 9781681080741
DOI https://doi.org/10.2174/97816810807411150101
Keywords Accessory proteins, Aspergillus, biofuel, CAZyme, gene regulation, inducer, light, lignocellulose, mixed culture, model, Neurospora, nucleosome, pH, saccharification, signalling, stresses, transcription factor, transporter, Trichoderma, XlnR/XYR1/XLR-1
Public URL http://eprints.nottingham.ac.uk/id/eprint/42230
Publisher URL http://www.eurekaselect.com/132939/volume/1
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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