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Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients

Ravipati, Srinivasarao; Baldwin, David R.; Barr, Helen L.; Fogarty, Andrew W.; Barrett, David A.

Authors

Srinivasarao Ravipati

David R. Baldwin

Helen L. Barr

ANDREW FOGARTY andrew.fogarty@nottingham.ac.uk
Clinical Associate Professor & Reader in Clinical Epidemiology

David A. Barrett david.barrett@nottingham.ac.uk



Abstract

There is a clinical need for reliable biomarkers for lung cancer that permit early diagnosis of the disease and provide prediction of histological phenotype. A prospective study design was used with a study population of patients with suspected lung cancer. Blood samples were collected from 17 patients with histologically confirmed squamous cell lung carcinoma, 17 individuals with adenocarcinoma, and 17 control individuals who did not subsequently have a diagnosis of lung cancer or any other cancer. Blood plasma samples were analysed for their lipid profiles using liquid chromatography coupled with high resolution mass spectrometry. Data were analysed using multivariate statistical methods. There was good separation between histological subtypes and control groups and also between individuals with a subsequent diagnosis of adenocarcinoma and squamous cell carcinoma (sensitivity 80 %, specificity 83 %, Q2 = 0.70). Alterations in the levels of different classes of lipids including triglycerides (TGs), phosphatidylinositols (PIs), phosphatidylcholines (PCs), phosphatidylethanolamines (PEs), free fatty acids, lysophospholipids and sphingolipids were observed in squamous carcinoma and adenocarcinoma lung cancer patients when compared with control patients. In conclusion, this study has identified candidate lipid biomarkers of non-small cell lung cancer patients which may be helpful to indicate the tumour subtype and to differentiate them from patients who do not have lung cancer. Measuring these biomarkers has the potential to improve diagnosis in patients with suspected lung cancer and risk stratification in screening.

Citation

Ravipati, S., Baldwin, D. R., Barr, H. L., Fogarty, A. W., & Barrett, D. A. (in press). Plasma lipid biomarker signatures in squamous carcinoma and adenocarcinoma lung cancer patients. Metabolomics, 11(6), https://doi.org/10.1007/s11306-015-0811-x

Journal Article Type Article
Acceptance Date May 19, 2015
Online Publication Date May 26, 2015
Deposit Date Nov 22, 2016
Publicly Available Date Nov 22, 2016
Journal Metabolomics
Electronic ISSN 1573-3890
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 11
Issue 6
DOI https://doi.org/10.1007/s11306-015-0811-x
Keywords lung cancer, squamous carcinoma, adenocarcinoma, lipidomics
Public URL http://eprints.nottingham.ac.uk/id/eprint/38882
Publisher URL http://link.springer.com/article/10.1007%2Fs11306-015-0811-x
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf
Additional Information The final publication is available at Springer via http://dx.doi.org/10.1007/s11306-015-0811-x

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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