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Estimating the within-household infection rate in emerging SIR epidemics among a community of households

Ball, Frank; Shaw, Laurence

Authors

FRANK BALL frank.ball@nottingham.ac.uk
Professor of Applied Probability

Laurence Shaw



Abstract

This paper is concerned with estimation of the within household infection rate λL for a susceptible → infective → recovered epidemic among a population of households, from observation of the early, exponentially growing phase of an epidemic. Specifically, it is assumed that an estimate of the exponential growth rate is available from general data on an emerging epidemic and more-detailed, household-level data are available in a sample of households. Estimates of λL obtained using the final size distribution of single-household epidemics are usually biased owing to the emerging nature of the epidemic. A new method, which accounts correctly for the emerging nature of the epidemic, is developed by exploiting the asymptotic theory of supercritical branching processes and proved to yield a strongly consistent estimator of λL as the population and sampled households both tend to infinity in an appropriate fashion. The theory is illustrated by simulations which demonstrate that the new method is feasible for finite populations and numerical studies are used to explore how changes to the parameters governing the spread of an epidemic affect the bias of estimates based on single-household final size distributions.

Journal Article Type Article
Journal Journal of Mathematical Biology
Print ISSN 0303-6812
Electronic ISSN 1432-1416
Publisher Humana Press
Peer Reviewed Peer Reviewed
Volume 71
Issue 6
APA6 Citation Ball, F., & Shaw, L. (in press). Estimating the within-household infection rate in emerging SIR epidemics among a community of households. Journal of Mathematical Biology, 71(6), doi:10.1007/s00285-015-0872-5
DOI https://doi.org/10.1007/s00285-015-0872-5
Keywords Household epidemic model, SIR epidemic, Emerging epidemic,
Parameter estimation, Branching process
Publisher URL http://link.springer.com/article/10.1007/s00285-015-0872-5
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information The final publication is available at Springer via http://dx.doi.org/10.1007/s00285-015-0872-5.
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