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Incidence and distribution of coeliac disease in Campania (Italy): 2011–2013

Zingone, Fabiana; West, Joe; Auricchio, Renata; Maria Bevilacqua, Rosa; Bile, Guido; Borgheresi, Patrizia; Erminia Bottiglieri, Maria; Caldore, Mariano; Capece, Giuseppe; Cristina Caria, Maria; Crudele, Antonio; Cuomo, Rosario; Lucia Garofano, Maria; Giardullo, Nicola; Gerarda Gravina, Antonietta; Greco, Luigi; Iannotta, Patrizia; Kosova, Paolo; Lamanda, Roberto; Malamisura, Basilio; Marmo, Riccardo; Napoli, Gianfranco; Nardone, Gerardo; Pacelli, Maria; Pascarella, Filomena; Riccio, Elisabetta; Riegler, Gabriele; Rispo, Antonio; Rocco, Alba; Romano, Marco; Saffiotti, Ottavio; Saviano, Paola; Sorrentini, Italo; Speranza,, Pietro; Tolone, Carlo; Tortora, Raffaella; Troncone, Riccardo; Ciacci, Carolina

Authors

Fabiana Zingone

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology

Renata Auricchio

Rosa Maria Bevilacqua

Guido Bile

Patrizia Borgheresi

Maria Erminia Bottiglieri

Mariano Caldore

Giuseppe Capece

Maria Cristina Caria

Antonio Crudele

Rosario Cuomo

Maria Lucia Garofano

Nicola Giardullo

Antonietta Gerarda Gravina

Luigi Greco

Patrizia Iannotta

Paolo Kosova

Roberto Lamanda

Basilio Malamisura

Riccardo Marmo

Gianfranco Napoli

Gerardo Nardone

Maria Pacelli

Filomena Pascarella

Elisabetta Riccio

Gabriele Riegler

Antonio Rispo

Alba Rocco

Marco Romano

Ottavio Saffiotti

Paola Saviano

Italo Sorrentini

Pietro Speranza,

Carlo Tolone

Raffaella Tortora

Riccardo Troncone

Carolina Ciacci



Abstract

BACKGROUND: There exists a wide variation in the reported incidence of coeliac disease in recent decades. We aimed to evaluate the incidence rate of coeliac diagnoses performed in an Italian region, Campania, between 2011 and 2013 and its variation therein.

METHODS: All coeliac diagnoses made from 2011 to 2013 and registered within the Campania coeliac disease register (CeliacDB) were identified. Incidence rates were analysed by sex, age and province of residence, with a Poisson model fitted to determine incidence rate ratios.

RESULTS: We found 2049 coeliac disease diagnoses registered in the CeliacDB between 2011 and 2013; 1441 of these patients were female (70.4%) and 1059 were aged less than 19 years (51.7%). The overall incidence of coeliac disease in Campania was 11.8 per 100,000 person-years (95% CI 11.3–12.3) during the study period, with marked variation by age [27.4 per 100,000 person-years (95% CI 25.8–29.1) in children under 19 years of age and 7.3 per 100,000 (95% CI 6.8–7.8) in adults] and sex [16.1 per 100,000 person-years in females (95% CI 15.3–16.9) and 7.2 per 100,000 person-years in males (95% CI 6.6–7.8)]. Coeliac disease incidence was roughly similar in Naples, Salerno, Caserta and Avellino, but about half in Benevento. More than 80% of our study population was diagnosed by the combination of positive antitransglutaminase IgA and Marsh 3. More than half of the patients were symptomatic at the time of coeliac disease diagnosis (39.7% had a classical presentation and 21.1% a non-classical one according to the Oslo definition).

CONCLUSIONS: Coeliac disease incidence was roughly similar among Campania provinces, except in Benevento where it was about half, probably due to less awareness of coeliac disease in this area. The incidence of coeliac disease in Campania appears to be lower than that reported by most of the previous literature, suggesting the necessity of new coeliac awareness programmes.

Journal Article Type Article
Publication Date Apr 1, 2015
Journal United European Gastroenterology Journal
Print ISSN 2050-6406
Electronic ISSN 2050-6414
Publisher SAGE Publications (UK and US)
Peer Reviewed Peer Reviewed
Volume 3
Issue 2
APA6 Citation Zingone, F., West, J., Auricchio, R., Maria Bevilacqua, R., Bile, G., Borgheresi, P., …Ciacci, C. (2015). Incidence and distribution of coeliac disease in Campania (Italy): 2011–2013. United European Gastroenterology Journal, 3(2), doi:10.1177/2050640615571021
DOI https://doi.org/10.1177/2050640615571021
Keywords Coeliac disease, Incidence, Clinical presentation, Italy
Publisher URL http://ueg.sagepub.com/content/3/2/182
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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