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Normalisation of brain connectivity through compensatory behaviour, despite congenital hand absence

Hahamy, Avital; Sotiropoulos, Stamatios N.; Henderson Slater, David; Malach, Rafael; Johansen-Berg, Heidi; Makin, Tamar R.

Authors

Avital Hahamy

Stamatios N. Sotiropoulos

David Henderson Slater

Rafael Malach

Heidi Johansen-Berg

Tamar R. Makin



Abstract

Previously we showed, using task-evoked fMRI, that compensatory intact hand usage after amputation facilitates remapping of limb representations in the cortical territory of the missing hand (Makin et al., 2013a). Here we show that compensatory arm usage in individuals born without a hand (one-handers) reflects functional connectivity of spontaneous brain activity in the cortical hand region. Compared with two-handed controls, one-handers showed reduced symmetry of hand region inter-hemispheric resting-state functional connectivity and corticospinal white matter microstructure. Nevertheless, those one-handers who more frequently use their residual (handless) arm for typically bimanual daily tasks also showed more symmetrical functional connectivity of the hand region, demonstrating that adaptive behaviour drives long-range brain organisation. We therefore suggest that compensatory arm usage maintains symmetrical sensorimotor functional connectivity in one-handers. Since variability in spontaneous functional connectivity in our study reflects ecological behaviour, we propose that inter-hemispheric symmetry, typically observed in resting sensorimotor networks, depends on coordinated motor behaviour in daily life.

Journal Article Type Article
Publication Date Jan 6, 2015
Journal eLife
Electronic ISSN 2050-084X
Publisher eLife Sciences Publications
Peer Reviewed Peer Reviewed
Volume 4
Article Number e04605
APA6 Citation Hahamy, A., Sotiropoulos, S. N., Henderson Slater, D., Malach, R., Johansen-Berg, H., & Makin, T. R. (2015). Normalisation of brain connectivity through compensatory behaviour, despite congenital hand absence. eLife, 4, https://doi.org/10.7554/eLife.04605.001
DOI https://doi.org/10.7554/eLife.04605.001
Publisher URL https://elifesciences.org/articles/04605
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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