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Feature selection in detection of adverse drug reactions from the Health Improvement Network (THIN) database

Liu, Yihui; Aickelin, Uwe

Authors

Yihui Liu

Uwe Aickelin



Abstract

Adverse drug reaction (ADR) is widely concerned for public health issue. ADRs are one of most common causes to withdraw some drugs from market. Prescription event monitoring (PEM) is an important approach to detect the adverse drug reactions. The main problem to deal with this method is how to automatically extract the medical events or side effects from high-throughput medical events, which are collected from day to day clinical practice. In this study we propose a novel concept of feature matrix to detect the ADRs. Feature matrix, which is extracted from high-throughput medical data from The Health Improvement Network (THIN) database, is created to characterize the medical events for the patients who take drugs. Feature matrix builds the foundation for the irregular and high-throughput medical data. Then feature selection methods are performed on feature matrix to detect the significant features. Finally the ADRs can be located based on the significant features. The experiments are carried out on three drugs: Atorvastatin, Alendronate, and Metoclopramide. Major side effects for each drug are detected and better performance is achieved compared to other computerized methods. The detected ADRs are based on computerized methods, further investigation is needed.

Journal Article Type Article
Publication Date Feb 1, 2015
Journal International Journal of Information Technology and Computer Science
Electronic ISSN 2074-9015
Peer Reviewed Peer Reviewed
Volume 7
Issue 3
APA6 Citation Liu, Y., & Aickelin, U. (2015). Feature selection in detection of adverse drug reactions from the Health Improvement Network (THIN) database. doi:10.5815/ijitcs.2015.03.10
DOI https://doi.org/10.5815/ijitcs.2015.03.10
Keywords Biomedical Informatics, Data Mining
Publisher URL http://www.mecs-press.org/ijitcs/ijitcs-v7-n3/v7n3-10.html
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf
Additional Information © MECS Publisher

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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