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Use of neuraminidase inhibitors for rapid containment of influenza: a systematic review and meta-analysis of individual and household transmission studies

Okoli, G.N.; Otete, H.E.; Beck, C.R.; Nguyen-Van-Tam, Jonathan

Authors

G.N. Okoli

H.E. Otete

C.R. Beck

Jonathan Nguyen-Van-Tam Jonathan.Van-Tam@nottingham.ac.uk



Abstract

Objectives: To assess the effectiveness of neuraminidase inhibitors for use in rapid containment of influenza.
Method: We conducted a systematic review and meta-analysis in accordance with the PRISMA statement. Healthcare databases and sources of grey literature were searched up to 2012 and records screened against protocol eligibility criteria. Data extraction and risk of bias assessments were performed using a piloted form. Results were synthesised narratively and we undertook meta-analyses to calculate pooled estimates of effect, statistical heterogeneity and assessed publication bias.
Findings: Nine randomised controlled trials (RCTs) and eight observational studies met the inclusion criteria. Neuraminidase inhibitors provided 67 to 89% protection for individuals following prophylaxis. Meta-analysis of individual protection showed a significantly lower pooled odds of laboratory confirmed seasonal or influenza A(H1N1) pdm09 infection following oseltamivir usage compared to placebo or no therapy (n=8 studies; odds ratio (OR) 50.11; 95% confidence interval (CI)=50.06 to 0.20; p

Journal Article Type Article
Publication Date Dec 9, 2014
Journal PLoS ONE
Electronic ISSN 1932-6203
Publisher Public Library of Science
Peer Reviewed Peer Reviewed
Volume 9
Issue 12
APA6 Citation Okoli, G., Otete, H., Beck, C., & Nguyen-Van-Tam, J. (2014). Use of neuraminidase inhibitors for rapid containment of influenza: a systematic review and meta-analysis of individual and household transmission studies. PLoS ONE, 9(12), https://doi.org/10.1371/journal.pone.0113633
DOI https://doi.org/10.1371/journal.pone.0113633
Keywords Randomized controlled-trial ; pandemic h1n1 2009 ;
oseltamivir treatment ; healthy-adults ; prevent influenza ;
zanamivir ; prophylaxis ; infection ; virus ; duration
Publisher URL http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0113633
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0





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