Lu Ban email@example.com
Limited risks of major congenital anomalies in children of mothers with coeliac disease: a population-based cohort study
Ban, Lu; West, Joe; Abdul Sultan, Alyshah; Dhalwani, Nafeesa N.; Ludvigsson, Jonas F.; Tata, Laila J.
JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology
Alyshah Abdul Sultan
Nafeesa N. Dhalwani
Jonas F. Ludvigsson
Dr LAILA TATA firstname.lastname@example.org
Objective: To examine major congenital anomaly (CA) risks in children of mothers with coeliac disease (CD) compared with mothers without CD.
Design: Population-based cohort study.
Setting: Linked maternal–child medical records from a large primary care database from the UK.
Population: A total of 562 332 live singletons of mothers with and without CD in 1990–2013.
Methods: We calculated the absolute major CA risks in children whose mothers had CD, and whether this was diagnosed or undiagnosed before childbirth. Logistic regression with a generalised estimating equation was used to estimate adjusted odds ratios (aORs) with 95% confidence intervals (95% CIs) for CAs associated with CD.
Main outcome measures: Fourteen system-specific major CA groups classified according to the European Surveillance of Congenital Anomalies and neural tube defects (NTDs).
Results: Major CA risk in 1880 children of mothers with CD was 293 per 10 000 liveborn singletons, similar to the risk in those without CD (282; aOR 0.98, 95% CI 0.74–1.30). The risk was slightly higher in 971 children, whose mothers were undiagnosed (350; aOR 1.14, 95% CI 0.79–1.64), than in 909 children whose mothers were diagnosed (231; aOR 0.80, 95% CI 0.52–1.24). There was a three-fold increase in nervous system anomalies in the children of mothers with undiagnosed CD (aOR 2.98, 95% CI 1.06–8.33, based on five exposed cases and one had an NTD), and these women were all diagnosed with CD at least 4 years after their children were born.
Conclusions: There was no statistically significant increase in risk of major CAs in children of mothers with coeliac disease overall, compared with the general population.
|Journal Article Type||Article|
|Journal||BJOG: An International Journal of Obstetrics & Gynaecology|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Ban, L., West, J., Abdul Sultan, A., Dhalwani, N. N., Ludvigsson, J. F., & Tata, L. J. (in press). Limited risks of major congenital anomalies in children of mothers with coeliac disease: a population-based cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 122(13), https://doi.org/10.1111/1471-0528.13102|
|Copyright Statement||Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0|
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0
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