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Limited risks of major congenital anomalies in children of mothers with coeliac disease: a population-based cohort study

Ban, Lu; West, Joe; Abdul Sultan, Alyshah; Dhalwani, Nafeesa N.; Ludvigsson, Jonas F.; Tata, Laila J.

Authors

Lu Ban lu.ban@nottingham.ac.ukl

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology

Alyshah Abdul Sultan

Nafeesa N. Dhalwani

Jonas F. Ludvigsson



Abstract

Objective: To examine major congenital anomaly (CA) risks in children of mothers with coeliac disease (CD) compared with mothers without CD.

Design: Population-based cohort study.

Setting: Linked maternal–child medical records from a large primary care database from the UK.

Population: A total of 562 332 live singletons of mothers with and without CD in 1990–2013.

Methods: We calculated the absolute major CA risks in children whose mothers had CD, and whether this was diagnosed or undiagnosed before childbirth. Logistic regression with a generalised estimating equation was used to estimate adjusted odds ratios (aORs) with 95% confidence intervals (95% CIs) for CAs associated with CD.

Main outcome measures: Fourteen system-specific major CA groups classified according to the European Surveillance of Congenital Anomalies and neural tube defects (NTDs).

Results: Major CA risk in 1880 children of mothers with CD was 293 per 10 000 liveborn singletons, similar to the risk in those without CD (282; aOR 0.98, 95% CI 0.74–1.30). The risk was slightly higher in 971 children, whose mothers were undiagnosed (350; aOR 1.14, 95% CI 0.79–1.64), than in 909 children whose mothers were diagnosed (231; aOR 0.80, 95% CI 0.52–1.24). There was a three-fold increase in nervous system anomalies in the children of mothers with undiagnosed CD (aOR 2.98, 95% CI 1.06–8.33, based on five exposed cases and one had an NTD), and these women were all diagnosed with CD at least 4 years after their children were born.

Conclusions: There was no statistically significant increase in risk of major CAs in children of mothers with coeliac disease overall, compared with the general population.

Journal Article Type Article
Journal BJOG: An International Journal of Obstetrics & Gynaecology
Print ISSN 1470-0328
Electronic ISSN 1471-0528
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 122
Issue 13
APA6 Citation Ban, L., West, J., Abdul Sultan, A., Dhalwani, N. N., Ludvigsson, J. F., & Tata, L. J. (in press). Limited risks of major congenital anomalies in children of mothers with coeliac disease: a population-based cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 122(13), https://doi.org/10.1111/1471-0528.13102
DOI https://doi.org/10.1111/1471-0528.13102
Keywords Abnormalities
coeliac disease
congenital epidemiology
Publisher URL http://onlinelibrary.wiley.com/doi/10.1111/1471-0528.13102/abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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