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Factors Associated With Smoking Cessation in Early and Late Pregnancy in the Smoking, Nicotine, and Pregnancy Trial: A Trial of Nicotine Replacement Therapy

Vaz, Luis R.; Leonardi-Bee, Jo; Aveyard, Paul; Cooper, Sue; Grainge, Matthew; Coleman, Tim

Authors

Luis R. Vaz

JO LEONARDI-BEE jo.leonardi-bee@nottingham.ac.uk
Professor of Medical Statistics and Epidemiology

Paul Aveyard

TIM COLEMAN tim.coleman@nottingham.ac.uk
Professor of Primary Care



Abstract

Introduction: Previous studies have found partners’ smoking status, multiparity, and nicotine dependence to be associated with smoking cessation in pregnancy. However, no studies have investigated influences on cessation among women using nicotine replacement therapy (NRT). We analyzed data from a trial of NRT in pregnancy to determine factors associated with shorter- and longer-term cessation.

Methods: Data were collected at baseline, 1 month, and delivery from 1,050 pregnant women. Two multivariable logistic models for validated cessation at 1 month and delivery were created with a systematic strategy for selection of included factors.

Results: All findings are from multivariable analyses. At 1 month, odds of cessation were greater among those who completed full time education at >16 years of age (odds ratio [OR] = 1.82, 95% confidence interval CI = 1.24–2.67, p = .002) but they were lower in women with higher baseline cotinine levels (OR = 0.93, 95% CI = 0.90–0.95, p < .001). At delivery, the odds of cessation were greater among those who completed full time education at >16 years of age (OR = 1.89, 95% CI = 1.16–3.07, p = 0.010) but were inversely associated with higher baseline cotinine levels (OR = 0.96, 95% CI = 0.92–0.99, p = .010).

Conclusions: Women who are better educated and have lower pretreatment cotinine concentrations had higher odds of stopping smoking and factors associated with shorter and longer term cessation were similar.

Journal Article Type Article
Publication Date 2014-04
Journal Nicotine & Tobacco Research
Electronic ISSN 1469-994X
Publisher Oxford University Press
Peer Reviewed Peer Reviewed
Volume 16
Issue 4
Pages 381-389
APA6 Citation Vaz, L. R., Leonardi-Bee, J., Aveyard, P., Cooper, S., Grainge, M., & Coleman, T. (2014). Factors Associated With Smoking Cessation in Early and Late Pregnancy in the Smoking, Nicotine, and Pregnancy Trial: A Trial of Nicotine Replacement Therapy. Nicotine and Tobacco Research, 16(4), 381-389. https://doi.org/10.1093/ntr/ntt156
DOI https://doi.org/10.1093/ntr/ntt156
Publisher URL https://academic.oup.com/ntr/article/16/4/381/1170964
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0

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