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The incidence and prevalence of systemic lupus erythematosus in the UK, 1999–2012

Rees, Frances; Doherty, Michael; Grainge, Matthew J.; Davenport, Graham; Lanyon, Peter; Zhang, Weiya

Authors

Frances Rees

Michael Doherty

Graham Davenport

Peter Lanyon



Abstract

Objectives: To estimate the incidence and prevalence of systemic lupus erythematosus (SLE) in the UK over the period 1999–2012.

Methods: A retrospective cohort study using the Clinical Practice Research Datalink (CPRD). The incidence was calculated per 100 000 person-years and the prevalence was calculated per 100 000 people for the period 1999–2012 and stratified by year, age group, gender, region and ethnicity. Three definitions of SLE were explored: (1) systemic lupus, (2) a fully comprehensive definition of lupus including cutaneous only lupus and (3) requiring supporting evidence of SLE in the medical record.

Results: Using our primary definition of SLE, the incidence during the study period was 4.91/100 000 person-years (95% CI 4.73 to 5.09), with an annual 1.8% decline (p

Citation

Rees, F., Doherty, M., Grainge, M. J., Davenport, G., Lanyon, P., & Zhang, W. (in press). The incidence and prevalence of systemic lupus erythematosus in the UK, 1999–2012. Annals of the Rheumatic Diseases, 75(1), https://doi.org/10.1136/annrheumdis-2014-206334

Journal Article Type Article
Acceptance Date Sep 13, 2014
Online Publication Date Sep 29, 2014
Deposit Date Aug 15, 2016
Publicly Available Date Aug 15, 2016
Journal Annals of the Rheumatic Diseases
Print ISSN 0003-4967
Electronic ISSN 1468-2060
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 75
Issue 1
DOI https://doi.org/10.1136/annrheumdis-2014-206334
Keywords Autoimmune Diseases, Epidemiology, systemic lupus erythematosus
Public URL http://eprints.nottingham.ac.uk/id/eprint/35849
Publisher URL http://ard.bmj.com/content/75/1/136
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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