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The incidence and prevalence of systemic lupus erythematosus in the UK, 1999–2012

Rees, Frances; Doherty, Michael; Grainge, Matthew J.; Davenport, Graham; Lanyon, Peter; Zhang, Weiya

Authors

Frances Rees

Michael Doherty

Graham Davenport

Peter Lanyon



Abstract

Objectives: To estimate the incidence and prevalence of systemic lupus erythematosus (SLE) in the UK over the period 1999–2012.

Methods: A retrospective cohort study using the Clinical Practice Research Datalink (CPRD). The incidence was calculated per 100 000 person-years and the prevalence was calculated per 100 000 people for the period 1999–2012 and stratified by year, age group, gender, region and ethnicity. Three definitions of SLE were explored: (1) systemic lupus, (2) a fully comprehensive definition of lupus including cutaneous only lupus and (3) requiring supporting evidence of SLE in the medical record.

Results: Using our primary definition of SLE, the incidence during the study period was 4.91/100 000 person-years (95% CI 4.73 to 5.09), with an annual 1.8% decline (p

Journal Article Type Article
Journal Annals of the Rheumatic Diseases
Print ISSN 0003-4967
Electronic ISSN 1468-2060
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 75
Issue 1
APA6 Citation Rees, F., Doherty, M., Grainge, M. J., Davenport, G., Lanyon, P., & Zhang, W. (in press). The incidence and prevalence of systemic lupus erythematosus in the UK, 1999–2012. Annals of the Rheumatic Diseases, 75(1), https://doi.org/10.1136/annrheumdis-2014-206334
DOI https://doi.org/10.1136/annrheumdis-2014-206334
Keywords Autoimmune Diseases, Epidemiology, systemic lupus erythematosus
Publisher URL http://ard.bmj.com/content/75/1/136
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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