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Methods for assessing the regenerative responses of neural tissue

Poser, Steven W.; Rueger, Maria Adele; Androutsellis-Theotokis, Andreas


Steven W. Poser

Maria Adele Rueger

Andreas Androutsellis-Theotokis


Bruno Christ

Jana Oerlecke

Peggy Stock


In order to establish novel therapeutic paradigms and advance the field of regenerative medicine, methods for their effective implementation as well as rigorous assessment of outcomes are critical. This is especially evident and challenging in the context of treating complex and devastating neurodegenerative disorders, such as Parkinson’s disease, multiple sclerosis, and ischemic stroke. Stem cell-based approaches offer great promise in addressing these conditions. Here, we demonstrate an approach for identifying factors that mobilize endogenous neural stem cells in the repair and recovery of the central nervous system of rodents, involving site-specific administration of growth factors that activate particular signal transduction pathways, and that allows for the assessment of outcome utilizing magnetic resonance imaging and immunohistochemistry.


Poser, S. W., Rueger, M. A., & Androutsellis-Theotokis, A. (2014). Methods for assessing the regenerative responses of neural tissue. In J. Oerlecke, B. Christ, & P. Stock (Eds.), Animal models for stem cell therapySpringer. doi:10.1007/978-1-4939-1453-1_24

Acceptance Date Aug 4, 2014
Publication Date Aug 4, 2014
Deposit Date May 12, 2017
Electronic ISSN 1064-3745
Peer Reviewed Peer Reviewed
Volume V
Issue 1213
Series Title Methods in molecular biology
Book Title Animal models for stem cell therapy
ISBN 9781493914531
Keywords Stem cells; Regenerative medicine; Neurodegeneration; Magnetic resonance imaging; Immunohistochemistry
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