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Women with celiac disease present with fertility problems no more often than women in the general population

Dhalwani, Nafeesa N.; West, Joe; Sultan, Alyshah Abdul; Ban, Lu; Tata, Laila J.

Authors

Nafeesa N. Dhalwani nnd2@le.ac.uk

JOE WEST JOE.WEST@NOTTINGHAM.AC.UK
Professor of Epidemiology

Alyshah Abdul Sultan alyshah.sultan@hotmail.com

Lu Ban lu.ban@nottingham.ac.ukl



Abstract

BACKGROUND & AIMS: Studies have associated infertility with celiac disease. However, these included small numbers of women attending infertility specialist services and subsequently screened for celiac disease, and therefore may not have been representative of the general population. We performed a large population-based study of infertility and celiac disease in women from the United Kingdom.

METHODS: We identified 2,426,225 women with prospective UK primary care records between 1990 and 2013 during their child-bearing years from The Health Improvement Network database. We estimated age-specific rates of new clinically recorded fertility problems among women with and without diagnosed celiac disease. Rates were stratified by whether celiac disease was diagnosed before the fertility problem or afterward and compared with rates in women without celiac disease using Poisson regression, adjusting for sociodemographics, comorbidities, and calendar time.

RESULTS: Age-specific rates of new clinically recorded fertility problems in 6506 women with celiac disease were similar to the rates in women without celiac disease (incidence rate ratio, 1.12; 95% confidence interval, 0.88-1.42 among women age 25-29 years). Rates of infertility among women without celiac disease were similar to those of women with celiac disease before and after diagnosis. However, rates were 41% higher among women diagnosed with celiac disease when they were 25-29 years old, compared with women in the same age group without celiac disease (incidence rate ratio, 1.41; 95% confidence interval, 1.03-1.92).

CONCLUSIONS: Women with celiac disease do not have a greater likelihood of clinically recorded fertility problems than women without celiac disease, either before or after diagnosis, except for higher reports of fertility problems between 25-39 years if diagnosed with CD. These findings should assure most women with celiac disease that they do not have an increased risk for fertility problems.

Journal Article Type Article
Journal Gastroenterology
Print ISSN 2308-2097
Electronic ISSN 0016-5085
Publisher Publishing House Zaslavsky
Peer Reviewed Peer Reviewed
Volume 147
Issue 6
Article Number 1267-1274.e1
APA6 Citation Dhalwani, N. N., West, J., Sultan, A. A., Ban, L., & Tata, L. J. (in press). Women with celiac disease present with fertility problems no more often than women in the general population. Gastroenterology, 147(6), https://doi.org/10.1053/j.gastro.2014.08.025
DOI https://doi.org/10.1053/j.gastro.2014.08.025
Keywords Food Allergy
Gluten
Risk Factor
Pregnancy
Publisher URL http://www.sciencedirect.com/science/article/pii/S0016508514010361
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc-nd/4.0





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