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The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs)

Rogers, H.A.; Ward, J.H.; Miller, S.; Lowe, J.; Coyle, B.; Grundy, Richard G.

Authors

H.A. Rogers

J.H. Ward

S. Miller

J. Lowe

B. Coyle

Richard G. Grundy



Abstract

Background: Central nervous system primitive neuroectodermal tumours (CNS PNETs) are embryonal tumours occurring predominantly in children. Current lack of knowledge regarding their underlying biology hinders development of more effective treatments. We previously identified WNT/β-catenin pathway activation in one-third of CNS PNETs, which was potentially linked to a better prognosis. In this study, we have extended our cohort, achieving a statistically significant correlation with prognosis. We additionally investigated the biological effects of WNT/β-catenin pathway activation in tumour pathogenesis.
Methods: A total of 42 primary and 8 recurrent CNS PNETs were analysed for WNT/β-catenin pathway status using β-catenin immunohistochemistry. Genomic copy number and mRNA expression data were analysed to identify a molecular profile linked to WNT/β-catenin pathway activation.
results: Pathway activation was seen in 26% of CNS PNETs and was significantly associated with longer overall survival. Genes displaying a significant difference in expression levels, between tumours with and without WNT/β-catenin pathway activation, included several involved in normal CNS development suggesting aberrant pathway activation may be disrupting this process.
conclusion: We have identified WNT/β-catenin pathway status as a marker, which could potentially be used to stratify disease risk for patients with CNS PNET. Gene expression data suggest pathway activation is disrupting normal differentiation in the CNS.

Journal Article Type Article
Publication Date May 28, 2013
Journal British Journal of Cancer
Print ISSN 0007-0920
Electronic ISSN 0007-0920
Publisher Cancer Research UK
Peer Reviewed Peer Reviewed
Volume 108
APA6 Citation Rogers, H., Ward, J., Miller, S., Lowe, J., Coyle, B., & Grundy, R. G. (2013). The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs). British Journal of Cancer, 108, doi:10.1038/bjc.2013.170
DOI https://doi.org/10.1038/bjc.2013.170
Publisher URL http://www.nature.com/bjc/journal/v108/n10/full/bjc2013170a.html
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nd-sa/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nd-sa/4.0





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