Abishek Abhishek
Chondrocalcinosis is common in the absence of knee involvement
Abhishek, Abishek; Doherty, Sally; Maciewicz, Rose; Muir, Kenneth; Zhang, Weiya; Doherty, Michael
Authors
Sally Doherty
Rose Maciewicz
Kenneth Muir
Professor WEIYA ZHANG WEIYA.ZHANG@NOTTINGHAM.AC.UK
PROFESSOR OF EPIDEMIOLOGY
Michael Doherty
Abstract
Introduction: We aimed to describe the distribution of radiographic chondrocalcinosis (CC) and to examine
whether metacarpophalangeal joint (MCPJ) calcification and CC at other joints occurs in the absence of knee
involvement.
Methods: This was a cross-sectional study embedded in the Genetics of Osteoarthritis and Lifestyle study (GOAL).
All participants (n = 3,170) had radiographs of the knees, hands, and pelvis. These were scored for radiographic
changes of osteoarthritis (OA), for CC at knees, hips, symphysis pubis, and wrists, and for MCPJ calcification. The
prevalence of MCPJ calcification and CC overall, at each joint, and in the presence or absence of knee involvement,
was calculated.
Results: The knee was the commonest site of CC, followed by wrists, hips, and symphysis pubis. CC was more
likely to be bilateral at knees and wrists but unilateral at hips. MCPJ calcification was usually bilateral, and less
common than CC at knees, hips, wrists, and symphysis pubis. Unlike that previously reported, CC commonly
occurred without any knee involvement; 44.4% of wrist CC, 45.9% of hip CC, 45.5% of symphysis pubis CC, and
31.3% of MCPJ calcification occurred in patients without knee CC. Those with meniscal or hyaline articular cartilage
CC had comparable ages (P = 0.21), and neither preferentially associated with fibrocartilage CC at distant joints.
Conclusions: CC visualized on a plain radiograph commonly occurs at other joints in the absence of radiographic
knee CC. Therefore, knee radiographs alone are an insufficient screening test for CC. This has significant
implications for clinical practice, for epidemiologic and genetic studies of CC, and for the definition of OA patients
with coexistent crystal deposition.
Citation
Abhishek, A., Doherty, S., Maciewicz, R., Muir, K., Zhang, W., & Doherty, M. (2012). Chondrocalcinosis is common in the absence of knee involvement. Arthritis Research and Therapy, 14(5), Article 5. https://doi.org/10.1186/ar4043
Journal Article Type | Article |
---|---|
Publication Date | Oct 4, 2012 |
Deposit Date | Apr 11, 2014 |
Publicly Available Date | Apr 11, 2014 |
Journal | Arthritis Research & Therapy |
Print ISSN | 1478-6354 |
Electronic ISSN | 1478-6362 |
Publisher | BioMed Central |
Peer Reviewed | Peer Reviewed |
Volume | 14 |
Issue | 5 |
Article Number | 5 |
DOI | https://doi.org/10.1186/ar4043 |
Public URL | https://nottingham-repository.worktribe.com/output/711909 |
Publisher URL | http://arthritis-research.com/content/14/5/R205/abstract |
Files
ar4043.pdf
(271 Kb)
PDF
Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by/4.0
You might also like
Association Between Hyperuricemia and Ultrasound-Detected Hand Synovitis
(2024)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: discovery-access-systems@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2025
Advanced Search