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Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis

Hurley, M.N.; Cámara, Miguel; Smyth, Alan R.

Authors

M.N. Hurley

Miguel Cámara

Alan R. Smyth



Abstract

Pseudomonas aeruginosa chronically infects patients with cystic fibrosis and is associated with greater morbidity. There has been limited progress on the clinical development of new antibiotics with novel modes of action. This review addresses some of the latest research developments on the exploitation of candidate adjuvant therapeutic agents that may act alongside conventional antibiotics as an alternative therapeutic strategy. After considering key mechanisms this opportunistic pathogen employs to control virulence, the progress of various strategies including the inhibition of quorum sensing, efflux pumps and lectins, and the use of iron chelators, bacteriophages, immunisation and immunotherapy is reviewed. Both therapeutic approaches in early development and clinical phase are discussed.

Journal Article Type Article
Publication Date Oct 1, 2012
Journal European Respiratory Journal
Print ISSN 0903-1936
Electronic ISSN 0903-1936
Publisher European Respiratory Society
Peer Reviewed Peer Reviewed
Volume 40
Issue 4
Institution Citation Hurley, M., Cámara, M., & Smyth, A. R. (2012). Novel approaches to the treatment of Pseudomonas aeruginosa infections in cystic fibrosis. European Respiratory Journal, 40(4), doi:10.1183/09031936.00042012
DOI https://doi.org/10.1183/09031936.00042012
Keywords Antibiotic resistance, Antibiotic treatment, Cystic fibrosis and chronic infections, Pseudomonas
Publisher URL http://erj.ersjournals.com/content/40/4/1014.abstract
Copyright Statement Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://creativecommons.org/licenses/by-nc/4.0





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