Cian O'Donnell
Dendritic spine dynamics regulate the long-term stability of synaptic plasticity
O'Donnell, Cian; Nolan, Matthew F.; van Rossum, Mark C.W.
Authors
Matthew F. Nolan
Mark C.W. van Rossum
Abstract
Long-term synaptic plasticity requires postsynaptic influx of Ca²⁺ and is accompanied by changes in dendritic spine size. Unless Ca²⁺ influx mechanisms and spine volume scale proportionally, changes in spine size will modify spine Ca²⁺ concentrations during subsequent synaptic activation. We show that the relationship between Ca²⁺ influx and spine volume is a fundamental determinant of synaptic stability. If Ca²⁺ influx is undercompensated for increases in spine size, then strong synapses are stabilized and synaptic strength distributions have a single peak. In contrast, overcompensation of Ca²⁺ influx leads to binary, persistent synaptic strengths with double-peaked distributions. Biophysical simulations predict that CA1 pyramidal neuron spines are undercompensating. This unifies experimental findings that weak synapses are more plastic than strong synapses, that synaptic strengths are unimodally distributed, and that potentiation saturates for a given stimulus strength. We conclude that structural plasticity provides a simple, local, and general mechanism that allows dendritic spines to foster both rapid memory formation and persistent memory storage.
Citation
O'Donnell, C., Nolan, M. F., & van Rossum, M. C. (2011). Dendritic spine dynamics regulate the long-term stability of synaptic plasticity. Journal of Neuroscience, 31(45), https://doi.org/10.1523/JNEUROSCI.2520-11.2011
Journal Article Type | Article |
---|---|
Acceptance Date | Aug 22, 2011 |
Publication Date | Nov 9, 2011 |
Deposit Date | Feb 7, 2018 |
Journal | Journal of Neuroscience |
Electronic ISSN | 1529-2401 |
Publisher | Society for Neuroscience |
Peer Reviewed | Peer Reviewed |
Volume | 31 |
Issue | 45 |
DOI | https://doi.org/10.1523/JNEUROSCI.2520-11.2011 |
Public URL | https://nottingham-repository.worktribe.com/output/708752 |
Publisher URL | http://www.jneurosci.org/content/31/45/16142 |
You might also like
Competitive plasticity to reduce the energetic costs of learning
(2023)
Working Paper
Estimating the energy requirements for long term memory formation
(2023)
Working Paper
Weight dependence in BCM leads to adjustable synaptic competition
(2022)
Journal Article
Electro-physiology Models of Cells with Spherical Geometry with Non-conducting Center
(2020)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: digital-library-support@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search