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The non-invasive biopsy: will urinary proteomics make the renal tissue biopsy redundant?

Bramham, K.; Mistry, H.D.; Poston, L.; Chappell, L.C.; Thompson, A.J.

Authors

K. Bramham

H.D. Mistry Hiten.mistry@nottingham.ac.uk

L. Poston

L.C. Chappell

A.J. Thompson

Abstract

Proteomics is a rapidly advancing technique which gives a functional insight into gene expression in living organisms. Urine is an ideal medium for study as it is readily available, easily obtained and less complex than other bodily fluids. Considerable progress has been made over the last 5 years in the study of urinary proteomics as a diagnostic tool for renal disease. The advantages of this technique over the traditional renal biopsy include accessibility, safety, the possibility of serial sampling, and the potential for non-invasive prognostic and diagnostic monitoring of disease and an individual’s response to treatment. Urinary proteomics is now moving from a discovery phase in small studies to a validation phase in much larger numbers of patients with renal disease. Whilst there are still some limitations in methodology, which are assessed in this review, the possibility of urinary proteomics replacing the invasive tissue biopsy for diagnosis of renal disease is becoming increasingly realistic.

Journal Article Type Article
Publication Date Aug 1, 2009
Journal QJM: An International Journal of Medicine
Print ISSN 1460-2725
Electronic ISSN 1460-2725
Publisher Oxford University Press (OUP)
Peer Reviewed Peer Reviewed
Volume 102
Issue 8
Institution Citation Bramham, K., Mistry, H., Poston, L., Chappell, L., & Thompson, A. (2009). The non-invasive biopsy: will urinary proteomics make the renal tissue biopsy redundant?. QJM: An International Journal of Medicine, 102(8), doi:10.1093/qjmed/hcp071
DOI https://doi.org/10.1093/qjmed/hcp071
Publisher URL https://academic.oup.com/qjmed/article-lookup/doi/10.1093/qjmed/hcp071
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf




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