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Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies

Mistry, Hiten D.; Wilson, Vicky; Ramsay, Margaret M.; Symonds, Michael E.; Broughton Pipkin, Fiona

Authors

Hiten D. Mistry hiten.mistry@nottingham.ac.uk

Vicky Wilson

Margaret M. Ramsay

Michael E. Symonds

Fiona Broughton Pipkin



Abstract

Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Preeclampsia may also predispose the fetus to increased risks of adult cardiovascular disease. Selenium, acting through the selenoprotein glutathione peroxidases, has critical roles in regulating antioxidant status. Recent reports implicate poor maternal selenium status as a nutritional factor predisposing the mother to preeclampsia but the fetus and placenta have not been studied in tandem. Measurement of selenium concentrations, expression and activity levels of glutathione peroxidase and markers of oxidative stress were performed on maternal and umbilical venous blood samples or the placenta from 27 normal pregnant, 25 preeclamptic and 22 healthy age-matched non-pregnant women. The results of this study revealed highly significant reductions in serum selenium concentrations and plasma glutathione peroxidase activity in pregnancy per se compared to non-pregnant controls. Moreover, these levels were further decreased in the preeclamptic mothers and babies compared to normal pregnancies. Umbilical venous selenium was particularly low (42.1±11.8 and 29.0 ± 9.9 mug/L; mean ±s.d.; P

Journal Article Type Article
Publication Date Nov 1, 2008
Journal Hypertension
Print ISSN 2224-1485
Electronic ISSN 0194-911X
Publisher Publishing House Zaslavsky
Peer Reviewed Peer Reviewed
Volume 52
Institution Citation Mistry, H. D., Wilson, V., Ramsay, M. M., Symonds, M. E., & Broughton Pipkin, F. (2008). Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Hypertension, 52, doi:10.1161/HYPERTENSIONAHA.108.116103
DOI https://doi.org/10.1161/HYPERTENSIONAHA.108.116103
Keywords pregnancy, human, oxidative stress, selenium, glutathione peroxidase, preeclampsia, placenta
Publisher URL http://hyper.ahajournals.org/content/52/5/881
Copyright Statement Copyright information regarding this work can be found at the following address: http://eprints.nottingh.../end_user_agreement.pdf

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Copyright Statement
Copyright information regarding this work can be found at the following address: http://eprints.nottingham.ac.uk/end_user_agreement.pdf





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