Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies

Mistry, Hiten D.; Wilson, Vicky; Ramsay, Margaret M.; Symonds, Michael E.; Broughton Pipkin, Fiona

Abstract

Preeclampsia is a pregnancy-specific condition affecting 2-7% of women and a leading cause of perinatal and maternal morbidity and mortality. Preeclampsia may also predispose the fetus to increased risks of adult cardiovascular disease. Selenium, acting through the selenoprotein glutathione peroxidases, has critical roles in regulating antioxidant status. Recent reports implicate poor maternal selenium status as a nutritional factor predisposing the mother to preeclampsia but the fetus and placenta have not been studied in tandem. Measurement of selenium concentrations, expression and activity levels of glutathione peroxidase and markers of oxidative stress were performed on maternal and umbilical venous blood samples or the placenta from 27 normal pregnant, 25 preeclamptic and 22 healthy age-matched non-pregnant women. The results of this study revealed highly significant reductions in serum selenium concentrations and plasma glutathione peroxidase activity in pregnancy per se compared to non-pregnant controls. Moreover, these levels were further decreased in the preeclamptic mothers and babies compared to normal pregnancies. Umbilical venous selenium was particularly low (42.1±11.8 and 29.0 ± 9.9 mug/L; mean ±s.d.; P

Citation

Mistry, H. D., Wilson, V., Ramsay, M. M., Symonds, M. E., & Broughton Pipkin, F. (2008). Reduced selenium concentrations and glutathione peroxidase activity in preeclamptic pregnancies. Hypertension, 52, https://doi.org/10.1161/HYPERTENSIONAHA.108.116103

• Journal Article Type: Article
• Acceptance Date: Aug 21, 2008
• Publication Date: Nov 1, 2008
• Deposit Date: Jul 19, 2017
• Publicly Available Date: Jul 19, 2017
• Journal: Hypertension
• Print ISSN: 2224-1485
• Electronic ISSN: 0194-911X
• Publisher: Publishing House Zaslavsky
• Peer Reviewed: Peer Reviewed
• Volume: 52
• DOI: https://doi.org/10.1161/HYPERTENSIONAHA.108.116103
• Keywords: pregnancy, human, oxidative stress, selenium, glutathione peroxidase, preeclampsia, placenta
• Public URL: https://nottingham-repository.worktribe.com/output/705079
• Publisher URL: http://hyper.ahajournals.org/content/52/5/881