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Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi‐dose administration

Pesko, Bogumila; Habershon‐Butcher, Jocelyn; Muir, Tessa; Gray, Bob; Taylor, Polly; Fenwick, Susanna; Hincks, Pamela; Scarth, James; Paine, Stuart

Authors

Bogumila Pesko

Jocelyn Habershon‐Butcher

Tessa Muir

Bob Gray

Polly Taylor

Susanna Fenwick

Pamela Hincks

James Scarth



Abstract

Paracetamol is a widely used, non-opioid analgesic and antipyretic drug. Scientific evidence suggests that it is an effective pain treatment in equine medicine. However, there is very little published information about the pharmacokinetics of the drug in the horse. The aim of the research was to determine the pharmacokinetics of paracetamol in equine plasma and urine to inform treatment of Thoroughbred racehorses. In this multi-dose study, paracetamol was administered orally at 20 mg/kg to six Thoroughbred horses. Pre- and post-administration urine and plasma samples were collected and analysed using a quantitative liquid chromatography–tandem mass spectrometry (LC-MS/MS) method. Pharmacokinetic analysis of urine and plasma paracetamol clearance profiles was carried out, which enabled the calculation of possible screening limits (SL) that can regulate for a detection time of 120 h. Additionally, an estimation of orthocetamol concentration levels in urine was carried out to investigate any underlying relationship between the para- and ortho-isomers as both were suspected to contribute to basal levels, possibly due to environmental feed sources.

Open Research

Citation

Pesko, B., Habershon‐Butcher, J., Muir, T., Gray, B., Taylor, P., Fenwick, S., …Paine, S. (2021). Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi‐dose administration. Journal of Veterinary Pharmacology and Therapeutics, https://doi.org/10.1111/jvp.13024

Journal Article Type Article
Acceptance Date Sep 27, 2021
Online Publication Date Oct 13, 2021
Publication Date Oct 13, 2021
Deposit Date Nov 25, 2021
Publicly Available Date Oct 14, 2022
Journal Journal of Veterinary Pharmacology and Therapeutics
Print ISSN 0140-7783
Electronic ISSN 1365-2885
Publisher Wiley
Peer Reviewed Peer Reviewed
DOI https://doi.org/10.1111/jvp.13024
Keywords General Veterinary; Pharmacology
Public URL https://nottingham-repository.worktribe.com/output/6788109
Publisher URL https://onlinelibrary.wiley.com/doi/10.1111/jvp.13024
Additional Information This is the peer reviewed version of the following article: Pesko, B., Habershon-Butcher, J., Muir, T., Gray, B., Taylor, P., Fenwick, S., Hincks, P., Scarth, J., & Paine, S. (2021). Pharmacokinetics of paracetamol in the Thoroughbred horse following an oral multi-dose administration. Journal of Veterinary Pharmacology and Therapeutics, 00, 1– 9, which has been published in final form at https://doi.org/10.1111/jvp.13024. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.