Martina Letizia Contente
Stereoselective Reduction of Prochiral Cyclic 1,3-Diketones Using Different Biocatalysts
Contente, Martina Letizia; Dall�Oglio, Federica; Annunziata, Francesca; Molinari, Francesco; Rabuffetti, Marco; Romano, Diego; Tamborini, Lucia; Rother, D�rte; Pinto, Andrea
Authors
Federica Dall�Oglio
Francesca Annunziata
Francesco Molinari
Marco Rabuffetti
Diego Romano
Lucia Tamborini
D�rte Rother
Andrea Pinto
Abstract
We have developed biocatalytic methods for the stereoselective reduction of cyclic prochiral 1,3-diketones for the production of optically active β-hydroxyketones and/or 1,3-diols. The recombinant ketoreductase KRED1-Pglu (formulated as purified catalyst) and whole cells of wild type Escherichia coli DE3 Star were used as biocatalysts, displaying different and sometimes complementary stereoselectivity, thus allowing the preparation of stereochemically pure β-hydroxyketones (12–66% isolated yields, > 99% e.e.) and 1,3-diols (40–60% isolated yields, > 99% e.e.).
Citation
Contente, M. L., Dall’Oglio, F., Annunziata, F., Molinari, F., Rabuffetti, M., Romano, D., …Pinto, A. (2020). Stereoselective Reduction of Prochiral Cyclic 1,3-Diketones Using Different Biocatalysts. Catalysis Letters, 150(4), 1176-1185. https://doi.org/10.1007/s10562-019-03015-y
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 27, 2019 |
Online Publication Date | Nov 7, 2019 |
Publication Date | 2020-04 |
Deposit Date | Sep 8, 2020 |
Publicly Available Date | Mar 29, 2024 |
Journal | Catalysis Letters |
Print ISSN | 1011-372X |
Electronic ISSN | 1572-879X |
Publisher | Springer Verlag |
Peer Reviewed | Peer Reviewed |
Volume | 150 |
Issue | 4 |
Pages | 1176-1185 |
DOI | https://doi.org/10.1007/s10562-019-03015-y |
Keywords | General Chemistry; Catalysis |
Public URL | https://nottingham-repository.worktribe.com/output/4890047 |
Publisher URL | https://link.springer.com/article/10.1007%2Fs10562-019-03015-y |
Additional Information | Received: 22 August 2019; Accepted: 27 October 2019; First Online: 7 November 2019; : ; : The authors declare no conflict of interest. |
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