Internationally, there is growing recognition of the social and economic impact of work-related stress and mental ill-health; and, in turn, of the relative importance of promoting mental wellbeing and preventing the onset of mental disorders at work and within the community. Understanding the financial cost of mental ill-health and work-related stress to society and organisations is an important avenue by which to assess the magnitude and significance of an occupational or public health problem (Leigh, 2006; Tarricone, 2006; Jo, 2014). However, it can also act an important source of information in which to develop the business case for health-centered workplace interventions and public policy. The aim of this book chapter is to to cultivate a better understanding and informed discourse at the interface between the disciplines of psychology and economics. In particular, we seek to integrate our empirical understanding of the link between work, mental health and organisational performance within an economic methodological perspective.