Elena Zakirova
Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses
Zakirova, Elena; Milomir, Kovac; Zhuravleva, Margarita; Rutland, Catrin; Rizvanov, Albert
Authors
Kovac Milomir
Margarita Zhuravleva
CATRIN RUTLAND CATRIN.RUTLAND@NOTTINGHAM.AC.UK
Associate Professor
Albert Rizvanov
Contributors
CATRIN RUTLAND CATRIN.RUTLAND@NOTTINGHAM.AC.UK
Editor
Albert Rizvanov
Editor
Abstract
Tendon and ligament injuries have always been complex to treat, with recovery often taking many months, if successful at all. This chapter looks at recent work undertaken using regenerative medicine, specifically gene therapy and the advances that have been made in equine therapy. It looks at the process from plasmid construction, in vitro testing through to trialing the equine-specific plasmid construct in horses with superficial digital flexor tendon (tendinitis) and suspensory ligament branch injuries. It also looks at the rationale for utilizing vascular endothelial growth factor (VEGF164) and a basic fibroblast growth factor (FGF2) for these trials and the cellular effects and potential mechanisms of actions.
Citation
Zakirova, E., Milomir, K., Zhuravleva, M., Rutland, C., & Rizvanov, A. (2020). Gene Therapy as a Modern Method of Treating Naturally Occurring Tendinitis and Desmitis in Horses. In C. Rutland, & A. Rizvanov (Eds.), Equine science. InTech. https://doi.org/10.5772/intechopen.92352
Acceptance Date | Jun 19, 2020 |
---|---|
Online Publication Date | Jun 19, 2020 |
Publication Date | 2020 |
Deposit Date | Jun 22, 2020 |
Publicly Available Date | Mar 29, 2024 |
Publisher | InTech |
Book Title | Equine science |
ISBN | 978183962316- |
DOI | https://doi.org/10.5772/intechopen.92352 |
Keywords | Horse, gene therapy, tissue regeneration, superficial digital flexor tendon, tendon injuries, suspensory ligament |
Public URL | https://nottingham-repository.worktribe.com/output/4701305 |
Publisher URL | https://www.intechopen.com/online-first/gene-therapy-as-a-modern-method-of-treating-naturally-occurring-tendinitis-and-desmitis-in-horses |
Files
Gene Therapy as a Modern Method
(1.8 Mb)
PDF
Publisher Licence URL
https://creativecommons.org/licenses/by/3.0/
You might also like
The METTL3 RNA Methyltransferase Regulates Transcriptional Networks in Prostate Cancer
(2022)
Journal Article
Anatomy, histology, development and functions of Ossa cordis: A review
(2022)
Journal Article
Downloadable Citations
About Repository@Nottingham
Administrator e-mail: digital-library-support@nottingham.ac.uk
This application uses the following open-source libraries:
SheetJS Community Edition
Apache License Version 2.0 (http://www.apache.org/licenses/)
PDF.js
Apache License Version 2.0 (http://www.apache.org/licenses/)
Font Awesome
SIL OFL 1.1 (http://scripts.sil.org/OFL)
MIT License (http://opensource.org/licenses/mit-license.html)
CC BY 3.0 ( http://creativecommons.org/licenses/by/3.0/)
Powered by Worktribe © 2024
Advanced Search