Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe

Veronesi, Giulia; Baldwin, David R.; Henschke, Claudia I.; Ghislandi, Simone; Iavicoli, Sergio; Oudkerk, Matthijs; De Koning, Harry J.; Shemesh, Joseph; Field, John K.; Zulueta, Javier J.; Horgan, Denis; Fiestas Navarrete, Lucia; Infante, Maurizio V.; Novellis, Pierluigi; Murray, Rachael L.; Peled, Nir; Rampinelli, Cristiano; Rocco, Gaetano; Rzyman, Witold; Scagliotti, Giorgio Vittorio; Tammemagi, Martin C.; Bertolaccini, Luca; Triphuridet, Natthaya; Yip, Rowena; Rossi, Alexia; Senan, Suresh; Ferrante, Giuseppe; Brain, Kate; van der Aalst, Carlijn; Bonomo, Lorenzo; Consonni, Dario; Van Meerbeeck, Jan P.; Maisonneuve, Patrick; Novello, Silvia; Devaraj, Anand; Saghir, Zaigham; Pelosi, Giuseppe

Abstract

Lung cancer screening (LCS) with low-dose computed tomography (LDCT) was demonstrated in the National Lung Screening Trial (NLST) to reduce mortality from the disease. European mortality data has recently become available from the Nelson randomized controlled trial, which confirmed lung cancer mortality reductions by 26% in men and 39‒61% in women. Recent studies in Europe and the USA also showed positive results in screening workers exposed to asbestos. All European experts attending the “Initiative for European Lung Screening (IELS)” — a large international group of physicians and other experts concerned with lung cancer — agreed that LDCT-LCS should be implemented in Europe. However, the economic impact of LDCT-LCS and guidelines for its effective and safe implementation still need to be formulated. To this purpose, the IELS was asked to prepare recommendations to implement LCS and examine outstanding issues. A subgroup carried out a comprehensive literature review on LDCT-LCS and presented findings at a meeting held in Milan in November 2018. The present recommendations reflect that consensus was reached.

Citation

Veronesi, G., Baldwin, D. R., Henschke, C. I., Ghislandi, S., Iavicoli, S., Oudkerk, M., …Pelosi, G. (2020). Recommendations for Implementing Lung Cancer Screening with Low-Dose Computed Tomography in Europe. Cancers, 12(6), Article 1672. https://doi.org/10.3390/cancers12061672

• Journal Article Type: Article
• Acceptance Date: Jun 17, 2020
• Online Publication Date: Jun 24, 2020
• Publication Date: Jun 1, 2020
• Deposit Date: Jun 18, 2020
• Publicly Available Date: Jun 19, 2020
• Journal: Cancers
• Electronic ISSN: 2072-6694
• Publisher: MDPI
• Peer Reviewed: Peer Reviewed
• Volume: 12
• Issue: 6
• Article Number: 1672
• DOI: https://doi.org/10.3390/cancers12061672
• Keywords: Cancer Research; Oncology
• Public URL: https://nottingham-repository.worktribe.com/output/4672505