Cumulative incidence of post-infection asthma or wheezing among young children clinically diagnosed with respiratory syncytial virus infection in the United States: A retrospective database analysis
Nguyen-Van-Tam, Jonathan; Wyffels, Veronique; Smulders, Maartje; Mazumder, Debasish; Tyagi, Rohit; Gupta, Nikhil; Gavart, Sandra; Fleischhackl, Roman
Background: Respiratory syncytial virus (RSV) infection is implicated in subsequent development of asthma/wheezing (AW) among term and pre-term infants. We describe the cumulative incidence of AW among hospitalized and ambulatory neonates/infants/toddlers following RSV infection diagnosis over three independent follow-up periods.
Methods: Between January 1, 2007 and March 31, 2016, patients aged 0-2 years old with first clinical diagnosis of RSV infection were identified using the Optum® integrated electronic health records and claims database. Patients diagnosed with AW ≤30 days
post-RSV diagnosis were excluded. Three cohorts with 1, 3 and 5 years of follow-up were stratified by presence or absence of specific RSV high-risk factors, including pre-term birth and pre-defined, pre-existing comorbidities. Descriptive statistics and logistic regression results were reported.
Results: Overall, 9811, 4524 and 1788 RSV-infected high-risk-factor negative patients were included in 1, 3 and 5-year independent cohorts, respectively. Of these, 6.5%, 6.9% and 5.8%, respectively had RSV-related hospitalization. By the end of follow-up, 14.9%, 28.2% and 36.3% had AW events. Overall, 3030, 1378 and 552 RSV-infected high-risk-factor positive patients were included in the respective cohorts. Of these, 11.4%, 11.1% and 11.6%, respectively were hospitalized with initial RSV infection and 18.1%, 32.9% and 37.9% had subsequent AW events within the follow-up period. Logistic regression confirmed RSV-related hospitalization significantly increased the likelihood of developing AW (P
|Journal Article Type||Article|
|Publication Date||Jun 12, 2020|
|Journal||Influenza and Other Respiratory Viruses|
|Peer Reviewed||Peer Reviewed|
|APA6 Citation||Nguyen-Van-Tam, J., Wyffels, V., Smulders, M., Mazumder, D., Tyagi, R., Gupta, N., …Fleischhackl, R. (2020). Cumulative incidence of post-infection asthma or wheezing among young children clinically diagnosed with respiratory syncytial virus infection in the United States: A retrospective database analysis. Influenza and Other Respiratory Viruses, https://doi.org/10.1111/irv.12770|