The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy
Kubale, Valentina; Prozorowska, Ewelina; Glocová, Kristýna; Slater, Lucy; Rutland, Catrin
CATRIN RUTLAND firstname.lastname@example.org
The G-protein-coupled receptors (GPCRs, also called seven-transmembrane receptor, 7TMRs, or heptahelical receptor) are a conserved family of seven transmembrane receptors which are essential not only in the healthy heart and blood vessels but also in for treatment and therapy of cardiovascular disease and failure. Heart failure is a global leading cause of morbidity and death and as such understanding 7TMRs, their functions, structures and potential for therapy is essential. This review will investigate the roles of the receptors in the healthy functioning cardiovascular system, and in cardiac disorders with an emphasis in cardiomyopathy. It will also explore the role of autoimmunity and autoantibodies against the G-protein-coupled receptors in cardiomyopathy.
Kubale, V., Prozorowska, E., Glocová, K., Slater, L., & Rutland, C. (2020). The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy. In D. Gaze (Ed.), . United Kingdom: IntechOpen. https://doi.org/10.5772/intechopen.92628
|Acceptance Date||Apr 22, 2020|
|Online Publication Date||May 19, 2020|
|Publication Date||May 19, 2020|
|Deposit Date||May 22, 2020|
|Keywords||angiotensin, adrenoreceptors, cardiomyopathy, heart disease, endothelin-1, muscarinic receptors, vascular|
This file is under embargo due to copyright reasons.
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