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The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy

Kubale, Valentina; Prozorowska, Ewelina; Glocová, Kristýna; Slater, Lucy; Rutland, Catrin

Authors

Valentina Kubale

Ewelina Prozorowska

Kristýna Glocová

Lucy Slater



Contributors

D.C. Gaze
Editor

Abstract

The G-protein-coupled receptors (GPCRs, also called seven-transmembrane receptor, 7TMRs, or heptahelical receptor) are a conserved family of seven transmembrane receptors which are essential not only in the healthy heart and blood vessels but also in for treatment and therapy of cardiovascular disease and failure. Heart failure is a global leading cause of morbidity and death and as such understanding 7TMRs, their functions, structures and potential for therapy is essential. This review will investigate the roles of the receptors in the healthy functioning cardiovascular system, and in cardiac disorders with an emphasis in cardiomyopathy. It will also explore the role of autoimmunity and autoantibodies against the G-protein-coupled receptors in cardiomyopathy.

Citation

Kubale, V., Prozorowska, E., Glocová, K., Slater, L., & Rutland, C. (2020). The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy. In D. Gaze (Ed.), . United Kingdom: IntechOpen. https://doi.org/10.5772/intechopen.92628

Acceptance Date Apr 22, 2020
Online Publication Date May 19, 2020
Publication Date May 19, 2020
Deposit Date May 22, 2020
DOI https://doi.org/10.5772/intechopen.92628
Keywords angiotensin, adrenoreceptors, cardiomyopathy, heart disease, endothelin-1, muscarinic receptors, vascular
Public URL https://nottingham-repository.worktribe.com/output/4487169
Publisher URL https://www.intechopen.com/online-first/the-function-of-seven-transmembrane-receptors-in-the-cardiovascular-system-and-their-role-in-the-dev