Valentina Kubale
The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy
Kubale, Valentina; Prozorowska, Ewelina; Glocov�, Krist�na; Slater, Lucy; Rutland, Catrin
Authors
Ewelina Prozorowska
Krist�na Glocov�
Lucy Slater
CATRIN RUTLAND CATRIN.RUTLAND@NOTTINGHAM.AC.UK
Associate Professor
Contributors
D.C. Gaze
Editor
Abstract
The G-protein-coupled receptors (GPCRs, also called seven-transmembrane receptor, 7TMRs, or heptahelical receptor) are a conserved family of seven transmembrane receptors which are essential not only in the healthy heart and blood vessels but also in for treatment and therapy of cardiovascular disease and failure. Heart failure is a global leading cause of morbidity and death and as such understanding 7TMRs, their functions, structures and potential for therapy is essential. This review will investigate the roles of the receptors in the healthy functioning cardiovascular system, and in cardiac disorders with an emphasis in cardiomyopathy. It will also explore the role of autoimmunity and autoantibodies against the G-protein-coupled receptors in cardiomyopathy.
Citation
Kubale, V., Prozorowska, E., Glocová, K., Slater, L., & Rutland, C. (2020). The Function of Seven Transmembrane Receptors in the Cardiovascular System and Their Role in the Development of Cardiomyopathy. In D. Gaze (Ed.), . United Kingdom: IntechOpen. https://doi.org/10.5772/intechopen.92628
Acceptance Date | Apr 22, 2020 |
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Online Publication Date | May 19, 2020 |
Publication Date | May 19, 2020 |
Deposit Date | May 22, 2020 |
Publicly Available Date | Mar 28, 2024 |
DOI | https://doi.org/10.5772/intechopen.92628 |
Keywords | angiotensin, adrenoreceptors, cardiomyopathy, heart disease, endothelin-1, muscarinic receptors, vascular |
Public URL | https://nottingham-repository.worktribe.com/output/4487169 |
Publisher URL | https://www.intechopen.com/online-first/the-function-of-seven-transmembrane-receptors-in-the-cardiovascular-system-and-their-role-in-the-dev |
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