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Assessing the quality of meta-analyses in systematic reviews in pharmaceutical research in Iran by 2016: A systematic review

Amanollahi, Alireza; Moradi-Lakeh, Maziar; Shokraneh, Farhad; Bashiri, Yousef; Mahmudi, Leily

Authors

Alireza Amanollahi

Maziar Moradi-Lakeh

Farhad Shokraneh

Yousef Bashiri

Leily Mahmudi liley.mahmudi@gmail.com



Abstract

© Iran University of Medical Sciences. Background: Meta-analyses, like all other studies, may be poorly designed and implemented. This study was designed to determine the quality of meta-analyses in systematic reviews in the field of pharmaceutical research in Iran. Methods: Web of Science Core Collection, EMBASE, Ovid Medline, CINAHL, Scopus, and PubMed were systematically searched on June 4, 2017. The search was limited to the researches in the field of pharmaceutical studies. Based on inclusion criteria, 104 systematic reviews with meta-analysis (SRMA) were selected and assessed using quality assessment tools introduced by Higgins. Results: Participants, experimental interventions, and outcomes were reported in all the articles. Comparator intervention and study design were correctly reported in 103 (99.04%) and 101 (97.12%) articles, respectively. The comprehensive search strategy was available only in 48 articles (46.16%), and there was no evidence of a comprehensive search in 56 articles (53.84%). Risk of bias was investigated in 78 articles (75%). Also, funnel plots were the most commonly used method for reporting the bias in 64 articles (46.42%). Conclusion: In many of the meta-analyses, several items of the tool that represented a high-quality meta-analysis were absent. According to the findings, the comprehensive search and quality assessment were not at an appropriate level. Thus, the importance of reproducibility of information and quality assessment of included studies should be emphasized.

Journal Article Type Review
Publication Date 2020
Journal Medical Journal of the Islamic Republic of Iran
Print ISSN 1016-1430
Electronic ISSN 2251-6840
Publisher Tehran University of Medical Sciences
Peer Reviewed Peer Reviewed
Volume 34
Issue 1
Article Number 30
APA6 Citation Amanollahi, A., Moradi-Lakeh, M., Shokraneh, F., Bashiri, Y., & Mahmudi, L. (2020). Assessing the quality of meta-analyses in systematic reviews in pharmaceutical research in Iran by 2016: A systematic review. Medical Journal of the Islamic Republic of Iran, 34(1), https://doi.org/10.34171/mjiri.34.30
DOI https://doi.org/10.34171/mjiri.34.30
Publisher URL http://mjiri.iums.ac.ir/article-1-5147-en.html

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