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Effects of dietary vegetable oils on mammary lipid-related genes in holstein dairy cows

Vargas-Bello-pérez, Einar; Geldsetzer-Mendoza, Carolina; Cancino-Padilla, Nathaly; Morales, María Sol; Leskinen, Heidi; Garnsworthy, Philip C.; Loor, Juan J.; Romero, Jaime

Authors

Einar Vargas-Bello-pérez

Carolina Geldsetzer-Mendoza

Nathaly Cancino-Padilla

María Sol Morales

Heidi Leskinen

Juan J. Loor

Jaime Romero



Abstract

© 2019 by the authors. Licensee MDPI, Basel, Switzerland. This study analyzed effects of vegetable oils fed to dairy cows on abundance of genes related to lipid metabolism in milk somatic cells (MSC). During 63 days, 15 cows were allocated to 3 treatments: a control diet with no added lipid the same diet supplemented with olive oil (OO, 30 g/kg DM) or hydrogenated vegetable oil (HVO, 30 g/kg DM). On days 21, 42 and 63, MSC were obtained from all cows. Relative abundance of genes involved in lipid metabolism in MSC from cows fed control on days 42 and 63 was compared with relative abundance at day 21 to evaluate fold-changes. Those genes without changes over the time were selected to analyze effects of OO and HVO. Compared with control, on day 42, PLIN2 and THRSP were upregulated by OO. Compared with control, on day 21, HVO up regulated ACACA, down regulated FABP3, and on day 63 THRSP and FABP4 were down regulated. Dietary oil supplementation (3% DM) had a modest nutrigenomic effect on different biological functions such as acetate and FA activation and intra-cellular transport, lipid droplet formation, and transcription regulation in MSC.

Citation

Vargas-Bello-pérez, E., Geldsetzer-Mendoza, C., Cancino-Padilla, N., Morales, M. S., Leskinen, H., Garnsworthy, P. C., …Romero, J. (2020). Effects of dietary vegetable oils on mammary lipid-related genes in holstein dairy cows. Animals, 10(1), https://doi.org/10.3390/ani10010057

Journal Article Type Article
Acceptance Date Dec 23, 2019
Online Publication Date Dec 27, 2019
Publication Date Jan 1, 2020
Deposit Date Feb 11, 2020
Publicly Available Date Feb 11, 2020
Journal Animals
Electronic ISSN 2076-2615
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 10
Issue 1
Article Number 57
DOI https://doi.org/10.3390/ani10010057
Public URL https://nottingham-repository.worktribe.com/output/3637527
Publisher URL https://www.mdpi.com/2076-2615/10/1/57

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Publisher Licence URL
http://creativecommons.org/licenses/by/4.0/





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