Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus

Coleman, Christopher M.; Matthews, Krystal L.; Goicochea, Lindsay; Frieman, Matthew B.

Abstract

The Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly emerging highly pathogenic virus causing almost 50% lethality in infected individuals. The development of a smallanimal model is critical for the understanding of this virus and to aid in development of countermeasures against MERS-CoV. We found that BALB/c, 129/SvEv and 129/SvEv STAT1 knockout mice are not permissive to MERS-CoV infection. The lack of infection may be due to the low level of mRNA and protein for the MERS-CoV receptor, dipeptidyl peptidase 4 (DPP4), in the lungs of mice. The low level of DPP4 in the lungs likely contributes to the lack of viral replication in these mouse models and suggests that a transgenic mouse model expressing DPP4 to higher levels is necessary to create a mouse model for MERS-CoV. © 2014 SGM.

Citation

Coleman, C. M., Matthews, K. L., Goicochea, L., & Frieman, M. B. (2014). Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus. Journal of General Virology, 95(PART 2), 408-412. https://doi.org/10.1099/vir.0.060640-0

• Journal Article Type: Article
• Acceptance Date: Nov 5, 2013
• Online Publication Date: Nov 6, 2013
• Publication Date: Feb 1, 2014
• Deposit Date: Dec 17, 2019
• Journal: Journal of General Virology
• Print ISSN: 0022-1317
• Electronic ISSN: 1465-2099
• Publisher: Microbiology Society
• Peer Reviewed: Peer Reviewed
• Volume: 95
• Issue: PART 2
• Pages: 408-412
• DOI: https://doi.org/10.1099/vir.0.060640-0
• Keywords: Virology
• Public URL: https://nottingham-repository.worktribe.com/output/3590353