Looking beyond the audiogram in ototoxicity associated with platinum-based chemotherapy

Baguley, David M; Prayuenyong, Pattarawadee

Abstract

© 2019, The Author(s). Introduction: Ototoxicity associated with platinum-based chemotherapy is highly prevalent and can cause detrimental consequences among cancer survivors. Discussion: In this article, we highlight important aspects of the evaluation of ototoxicity with the aim to increase awareness of Oncologists in this regard. Standard pure tone audiometry alone is inadequate for this context. Comprehensive and consistent hearing tests should be implemented in a monitoring and surveillance program. High-frequency audiometry (10–16kHz) is a sensitive tool in the detection of ototoxic hearing loss at onset. In addition to threshold audiometry, measures of speech comprehension (both in quiet and in noise) can add useful information in the evaluation of hearing in real-life situations. Not only hearing loss, but also tinnitus and imbalance are common in patients who receive platinum-based chemotherapy, and can cause debilitating effects upon quality of life in this population. Moreover, self-report measures associated with cochlear and vestibular handicaps can provide valuable information regarding the impact of ototoxicity. Conclusions: It is vital to build awareness about the variety and impact of the symptoms of ototoxicity. Comprehensive evaluation of hearing status along with self-reported impact of the cochlear and vestibular handicap should be implemented in a monitoring and surveillance program for appropriate investigation and management.

Citation

Baguley, D. M., & Prayuenyong, P. (2020). Looking beyond the audiogram in ototoxicity associated with platinum-based chemotherapy. Cancer Chemotherapy and Pharmacology, 85(2), 245-250. https://doi.org/10.1007/s00280-019-04012-z

• Journal Article Type: Article
• Acceptance Date: Dec 12, 2019
• Online Publication Date: Dec 21, 2019
• Publication Date: 2020-02
• Deposit Date: Dec 13, 2019
• Publicly Available Date: Dec 22, 2020
• Journal: Cancer Chemotherapy and Pharmacology
• Print ISSN: 0344-5704
• Electronic ISSN: 1432-0843
• Publisher: Springer Verlag
• Peer Reviewed: Peer Reviewed
• Volume: 85
• Issue: 2
• Pages: 245-250
• DOI: https://doi.org/10.1007/s00280-019-04012-z
• Keywords: Toxicology; Pharmacology (medical); Cancer Research; Oncology; Pharmacology
• Public URL: https://nottingham-repository.worktribe.com/output/3548179
• Publisher URL: https://link.springer.com/article/10.1007/s00280-019-04012-z
• Additional Information: This is a post-peer-review, pre-copyedit version of an article published in Cancer Chemotherapy and Pharmacology. The final authenticated version is available online at: http://dx.doi.org/10.1007/s00280-019-04012-z.