Carolina C. Fernandes
Measurement of brain lactate during visual stimulation using a long TE semi?LASER sequence at 7 T
Fernandes, Carolina C.; Lanz, Bernard; Chen, Chen; Morris, Peter G.
Authors
Bernard Lanz
Chen Chen
Peter G. Morris
Abstract
Estimation of metabolic changes during neuronal activation represents a challenge for in vivo MRS, especially for metabolites with low concentration and signal overlap, such as lactate. In this work, we aimed to evaluate the feasibility of detecting lactate during brain activation using a long urn:x-wiley:nbm:media:nbm4223:nbm4223-math-0001 (144 ms) semi‐LASER sequence at 7 T. urn:x-wiley:nbm:media:nbm4223:nbm4223-math-0002 spectra were acquired on healthy volunteers ( urn:x-wiley:nbm:media:nbm4223:nbm4223-math-0003) during a paradigm with 15 min of visual stimulation. Outer‐volume signals were further attenuated by the use of saturation slabs, and macromolecular signals in the vicinity of the inverted lactate peak were individually fitted with simulated Lorentzian peaks. All spectra were free of artefacts and highly reproducible across subjects. Lactate was accurately quantified with an average Cramér‐Rao lower bound of 8%. Statistically significant ( urn:x-wiley:nbm:media:nbm4223:nbm4223-math-0004, one‐tailed urn:x-wiley:nbm:media:nbm4223:nbm4223-math-0005‐test) increases in lactate ( urn:x-wiley:nbm:media:nbm4223:nbm4223-math-000610%) and glutamate ( urn:x-wiley:nbm:media:nbm4223:nbm4223-math-00073%) levels during stimulation were detected in the visual cortex. Lactate and glutamate changes were consistent with previous measurements. We demonstrated that quantification of a clear and non‐contaminated lactate peak obtained with a long TE sequence has the potential of improving the accuracy of functional MRS studies targeting non‐oxidative reaction pathways.
Citation
Fernandes, C. C., Lanz, B., Chen, C., & Morris, P. G. (2020). Measurement of brain lactate during visual stimulation using a long TE semi?LASER sequence at 7 T. NMR in Biomedicine, 33(4), https://doi.org/10.1002/nbm.4223
Journal Article Type | Article |
---|---|
Acceptance Date | Oct 22, 2019 |
Online Publication Date | Jan 29, 2020 |
Publication Date | Apr 1, 2020 |
Deposit Date | Dec 4, 2019 |
Publicly Available Date | Dec 4, 2019 |
Journal | NMR in Biomedicine |
Print ISSN | 0952-3480 |
Electronic ISSN | 1099-1492 |
Publisher | Wiley |
Peer Reviewed | Peer Reviewed |
Volume | 33 |
Issue | 4 |
Article Number | e4223 |
DOI | https://doi.org/10.1002/nbm.4223 |
Keywords | Spectroscopy; Molecular Medicine; Radiology Nuclear Medicine and imaging |
Public URL | https://nottingham-repository.worktribe.com/output/3477135 |
Publisher URL | https://onlinelibrary.wiley.com/doi/full/10.1002/nbm.4223 |
Additional Information | Received: 2019-04-29; Accepted: 2019-10-22; Published: 2020-01-29 |
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Measurement of brain lactate during visual stimulation
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