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Volume Changes After Traumatic Spinal Cord Injury in Animal Studies - A Systematic Review

Sharif-Alhoseini, Mahdi; Vahedi, Fariba; Omidbeigi, Mahmoud; Sharifi, Marzieh; Hassannejad, Zahra; Abdollah Zadegan, Shayan; Rezvan, Motahareh; Mokhatab, Mona; Sajadi, Kiavash; Shakouri-Motlagh, Aida; Shokraneh, Farhad; Vaccaro, Alexander R.; Rahimi-Movaghar, Vafa

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Authors

Mahdi Sharif-Alhoseini

Fariba Vahedi

Mahmoud Omidbeigi

Marzieh Sharifi

Zahra Hassannejad

Shayan Abdollah Zadegan

Motahareh Rezvan

Mona Mokhatab

Kiavash Sajadi

Aida Shakouri-Motlagh

Farhad Shokraneh

Alexander R. Vaccaro

Vafa Rahimi-Movaghar



Abstract

There are limited data on the lesion volume changes following spinal cord injury (SCI). In this study, a meta-analysis was performed to evaluate the volume size changes of the injured spinal cord over time among animal studies in traumatic SCI. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, we conducted a comprehensive electronic search of English literature of PubMed and EMBASE databases from 1946 to 2015 concerning the time-dependent changes in the volume of the spinal cord following mechanical traumatic SCI. A hand-search was also performed for non-interventional, non-molecular, and non-review studies. Quality appraisal, data extraction, qualitative and quantitative analyses were performed afterward. Of 11,561 articles yielded from electronic search, 49 articles were assessed for eligibility after reviewing of titles, abstracts, and references. Ultimately, 11 articles were eligible for quantitative synthesis. The ratio of lesion volume to spinal cord total volume increased over time. Avascularity appeared in spinal cord 4 hours after injury. During the first week, the spinal subarachnoid space decreased. The hemorrhagic lesion size peaked in 1 week and decreased thereafter. Significant loss of gray and white matter occurred from day 3 with a slower progression of white matter damage. Changes of lesion extent over time is critical in pathophysiologic processes after SCI. Early avascularity, rapid loss of gray matter, slow progression of white matter damage, and late cavitation are the pathophysiologic key points of SCI, which could be helpful in choosing the proper intervention on a timely basis.

Citation

Sharif-Alhoseini, M., Vahedi, F., Omidbeigi, M., Sharifi, M., Hassannejad, Z., Abdollah Zadegan, S., …Rahimi-Movaghar, V. (2019). Volume Changes After Traumatic Spinal Cord Injury in Animal Studies - A Systematic Review. Acta Medica Iranica, 57(6), 385-394. https://doi.org/10.18502/acta.v57i6.1885

Journal Article Type Article
Acceptance Date May 19, 2019
Online Publication Date Nov 17, 2019
Publication Date Nov 17, 2019
Deposit Date Nov 23, 2019
Publicly Available Date Mar 28, 2024
Journal Acta Medica Iranica
Print ISSN 0044-6025
Electronic ISSN http://acta.tums.ac.ir/index.php/acta/article/view/7684
Publisher Tehran University of Medical Sciences
Peer Reviewed Peer Reviewed
Volume 57
Issue 6
Pages 385-394
DOI https://doi.org/10.18502/acta.v57i6.1885
Keywords Spinal cord injuries; Animal models; Pathophysiology
Public URL https://nottingham-repository.worktribe.com/output/3366407
Publisher URL http://acta.tums.ac.ir/index.php/acta/article/view/7684

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