In situ non-invasive Raman spectroscopic characterisation of succinic acid polymorphism during segmented flow crystallisation

Pallipurath, Anuradha R.; Flandrin, Pierre-Baptiste; Wayment, Lois E.; Wilson, Chick C.; Robertson, Karen

Abstract

The kinetically regulated automated input crystalliser for Raman spectroscopy (KRAIC-R) combines highly controlled crystallisation environments, via tri segmented flow, with non-invasive confocal Raman spectroscopy. Taking advantage of the highly reproducible crystallisation environment within a segmented flow crystalliser and the non-invasive nature of confocal spectroscopy, we are able to shine light on the nucleation and growth of Raman active polymorphic materials without inducing unrepresentative crystallisation events through our analysis technique. Using the KRAIC-R we have probed the nucleation and subsequent growth of succinic acid. Succinic acid typically crystallises as ?-SA from solution-based crystallisation although some examples of a small proportion of ?-SA have been reported in the ?-SA product. Here we show that ?-SA and ?-SA nucleate concomitantly but undergo Ostwald ripening to a predominantly ?-SA product.

Citation

Pallipurath, A. R., Flandrin, P., Wayment, L. E., Wilson, C. C., & Robertson, K. (2019). In situ non-invasive Raman spectroscopic characterisation of succinic acid polymorphism during segmented flow crystallisation. Molecular Systems Design and Engineering, 5, 294-303. https://doi.org/10.1039/c9me00103d

• Journal Article Type: Article
• Acceptance Date: Oct 18, 2019
• Online Publication Date: Oct 18, 2019
• Publication Date: Oct 18, 2019
• Deposit Date: Nov 15, 2019
• Publicly Available Date: Oct 19, 2020
• Journal: Molecular Systems Design & Engineering
• Print ISSN: 2058-9689
• Electronic ISSN: 2058-9689
• Publisher: Royal Society of Chemistry
• Peer Reviewed: Peer Reviewed
• Volume: 5
• Pages: 294-303
• DOI: https://doi.org/10.1039/c9me00103d
• Public URL: https://nottingham-repository.worktribe.com/output/3288909
• Publisher URL: https://pubs.rsc.org/en/content/articlelanding/2020/ME/C9ME00103D#!divAbstract