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Navigating the landscape of core outcome set development in dermatology

Prinsen, Cecilia A.C.; Spuls, Phyllis I.; Kottner, Jan; Thomas, Kim S.; Apfelbacher, Christian; Chalmers, Joanne R.; Deckert, Stefanie; Furue, Masutaka; Gerbens, Louise; Kirkham, Jamie; Simpson, Eric L.; Alam, Murad; Balzer, Katrin; Beeckman, Dimitri; Eleftheriadou, Viktoria; Ezzedine, Khaled; Horbach, Sophie E.R.; Ingram, John R.; Layton, Alison M.; Weller, Karsten; Wild, Thomas; Wolkerstorfer, Albert; Williams, Hywel C.; Schmitt, Jochen


Cecilia A.C. Prinsen

Phyllis I. Spuls

Jan Kottner

Christian Apfelbacher

Joanne R. Chalmers

Stefanie Deckert

Masutaka Furue

Louise Gerbens

Jamie Kirkham

Eric L. Simpson

Murad Alam

Katrin Balzer

Dimitri Beeckman

Viktoria Eleftheriadou

Khaled Ezzedine

Sophie E.R. Horbach

John R. Ingram

Alison M. Layton

Karsten Weller

Thomas Wild

Albert Wolkerstorfer

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Professor of Dermato-Epidemiology

Jochen Schmitt


© 2019 American Academy of Dermatology, Inc. The development of core outcome sets (COSs; ie, a minimum set of core outcomes that should be measured and reported in all trials or in clinical practice for a specific condition) in dermatology is increasing in pace. A total of 44 dermatology-related COS projects have been registered in the online Core Outcome Measures in Effectiveness Trials database ( and include studies on 26 different skin diseases. With the increasing number of COSs in dermatology, care is needed to ensure the delivery of high-quality COSs that meet quality standards when using state-of-the-art methods. In 2015, the Cochrane Skin–Core Outcome Set Initiative (CS-COUSIN) was established. CS-COUSIN is an international, multidisciplinary working group aiming to improve the development and implementation of COSs in dermatology. CS-COUSIN has developed guidance on how to develop high-quality COSs for skin diseases and supports dermatology-specific COS initiatives. Currently, 17 COS development groups are affiliated with CS-COUSIN and following standardized COS development processes. To ensure successful uptake of COSs in dermatology, researchers, clinicians, systematic reviewers, guideline developers, and other stakeholders should use existing COSs in their work.


Prinsen, C. A., Spuls, P. I., Kottner, J., Thomas, K. S., Apfelbacher, C., Chalmers, J. R., …Schmitt, J. (2019). Navigating the landscape of core outcome set development in dermatology. Journal of The American Academy of Dermatology, 81(1), 297-305.

Journal Article Type Article
Acceptance Date Mar 4, 2019
Online Publication Date Mar 13, 2019
Publication Date Jul 1, 2019
Deposit Date Oct 21, 2019
Journal Journal of the American Academy of Dermatology
Print ISSN 0190-9622
Electronic ISSN 1097-6787
Publisher Elsevier
Peer Reviewed Peer Reviewed
Volume 81
Issue 1
Pages 297-305
Keywords Dermatology
Public URL