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The efficacy of statins as otoprotective agents: A systematic review

Prayuenyong, Pattarawadee; Kasbekar, Anand V.; Baguley, David M.


Pattarawadee Prayuenyong

Anand V. Kasbekar

David M. Baguley


Objective: This systematic review examined the current literature, summarized research findings and identified research gaps regarding the efficacy of statins on audiological outcomes.

Methods: Systematic search of electronic databases and grey literature was performed. Eligibility criteria was the study of a statin drug with report of audiological outcomes such as hearing, tinnitus, or balance in either human or animal studies. Data extraction and quality assessment were performed by two independently researchers. The characteristics of the study and research findings were collated and summarized. A narrative synthesis was conducted. Meta-analysis was not possible due to heterogeneity of the included studies.

Results: Analysis of searches yielded 17 studies meeting the criteria. Included studies had variable drug type and dosage, outcome measures, and associated inner ear conditions. Most animal experiments showed promising audiological outcomes after statin treatment, demonstrated by the results of auditory brain stem response, distortion product otoacoustic emissions, and inner ear histology. However, no clear effect can be discerned in human trials due to the mixed results, and heterogeneity in research methodology and quality. Audiological outcomes were not always correlated with cholesterol levels.

Conclusions: Statins remain a potential candidate as otoprotective agents which warrant further investigation.


Prayuenyong, P., Kasbekar, A. V., & Baguley, D. M. (2020). The efficacy of statins as otoprotective agents: A systematic review. Clinical Otolaryngology, 45(1), 21-31.

Journal Article Type Article
Acceptance Date Oct 7, 2019
Online Publication Date Oct 10, 2019
Publication Date Jan 1, 2020
Deposit Date Oct 15, 2019
Publicly Available Date Oct 11, 2020
Journal Clinical Otolaryngology
Print ISSN 1749-4478
Electronic ISSN 1749-4486
Publisher Wiley
Peer Reviewed Peer Reviewed
Volume 45
Issue 1
Pages 21-31
Keywords Statins, Hydroxymethylglutaryl-CoA reductase inhibitors, Otoprotection, Hearing, Audiogram
Public URL
Publisher URL
Additional Information This is the peer reviewed version of the following article: which has been published in final form at Prayuenyong, P. , Kasbekar, A. V. and Baguley, D. M. (2019), The efficacy of statins as otoprotective agents: A systematic review. Clin Otolaryngol. doi:10.1111/coa.13457. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.


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