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Long-Term Effects of Dietary Olive Oil and Hydrogenated Vegetable Oil on Expression of Lipogenic Genes in Subcutaneous Adipose Tissue of Dairy Cows

Vargas-Bello-P�rez, Einar; Bionaz, Massimo; Sciarresi-Arechabala, Pietro; Cancino-Padilla, Nathaly; Sol Morales, Mar�a; Romero, Jaime; Leskinen, Heidi; Garnsworthy, Philip C.; Loor, Juan J.

Long-Term Effects of Dietary Olive Oil and Hydrogenated Vegetable Oil on Expression of Lipogenic Genes in Subcutaneous Adipose Tissue of Dairy Cows Thumbnail


Authors

Einar Vargas-Bello-P�rez

Massimo Bionaz

Pietro Sciarresi-Arechabala

Nathaly Cancino-Padilla

Mar�a Sol Morales

Jaime Romero

Heidi Leskinen

Philip C. Garnsworthy

Juan J. Loor



Abstract

The objective of this study was to characterize the long-term transcriptomic effects of lipogenic genes in subcutaneous adipose tissue (SAT) of dairy cows supplemented with unsaturated (olive oil; OO) and saturated (hydrogenated vegetable oil; HVO) lipids. Cows were fed a control diet with no added lipid, or diets containing OO or HVO (n = 5 cows/group) for 63 days. SAT was obtained from the tail-head area at the onset of the study and after 21, 42, and 63 days of supplementation. Treatments had minor effects on expression of measured genes. Both fat supplements reduced expression of PPARG, HVO decreased transcription of the desaturase FADS2 and lipid droplet formation PLIN2, and OO increased transcription of FABP3. Both lipid treatments decreased expression of the transcription regulator SREBF1 and its chaperone (SCAP) during the first 21 days of treatment. Our data indicated that long-term feeding of OO and HVO have a relatively mild effect on expression of lipogenic genes in SAT of mid-lactating cows.

Citation

Vargas-Bello-Pérez, E., Bionaz, M., Sciarresi-Arechabala, P., Cancino-Padilla, N., Sol Morales, M., Romero, J., …Loor, J. J. (2019). Long-Term Effects of Dietary Olive Oil and Hydrogenated Vegetable Oil on Expression of Lipogenic Genes in Subcutaneous Adipose Tissue of Dairy Cows. Veterinary Sciences, 6(3), https://doi.org/10.3390/vetsci6030074

Journal Article Type Article
Acceptance Date Sep 12, 2019
Online Publication Date Sep 15, 2019
Publication Date Sep 15, 2019
Deposit Date Sep 26, 2019
Publicly Available Date Mar 28, 2024
Journal Veterinary Sciences
Electronic ISSN 2306-7381
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 6
Issue 3
Article Number 74
DOI https://doi.org/10.3390/vetsci6030074
Keywords Fat supplementation; Transcriptomics; Adipose tissue; Lipid metabolism; Lipogenic gene expression; Dairy cows
Public URL https://nottingham-repository.worktribe.com/output/2664704
Publisher URL https://www.mdpi.com/2306-7381/6/3/74

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