W. A. T. Gibby
Theory and Experiments on Multi-Ion Permeation and Selectivity in the NaChBac Ion Channel
Gibby, W. A. T.; Barabash, M. L.; Guardiani, C.; Luchinsky, D. G.; Fedorenko, O. A.; Roberts, S. K.; McClintock, P. V. E.
Authors
M. L. Barabash
C. Guardiani
D. G. Luchinsky
O. A. Fedorenko
S. K. Roberts
P. V. E. McClintock
Abstract
The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aims of comparing with experimental recordings of current versus voltage and concentration and extracting important permeation parameters. For self-consistency, the behavior of the model at the two-state, i.e., selective limit in linear response, must agree with recent results derived from an equilibrium statistical theory. The kinetic model provides a good fit to data, including the key result of an anomalous mole fraction effect.
Citation
Gibby, W. A. T., Barabash, M. L., Guardiani, C., Luchinsky, D. G., Fedorenko, O. A., Roberts, S. K., & McClintock, P. V. E. (2019). Theory and Experiments on Multi-Ion Permeation and Selectivity in the NaChBac Ion Channel. Fluctuation and Noise Letters, 18(02), 1-13. https://doi.org/10.1142/s0219477519400078
Journal Article Type | Article |
---|---|
Acceptance Date | Feb 7, 2019 |
Online Publication Date | May 29, 2019 |
Publication Date | 2019-06 |
Deposit Date | Aug 27, 2019 |
Publicly Available Date | Mar 28, 2024 |
Journal | Fluctuation and Noise Letters |
Print ISSN | 0219-4775 |
Electronic ISSN | 1793-6780 |
Publisher | World Scientific |
Peer Reviewed | Peer Reviewed |
Volume | 18 |
Issue | 02 |
Article Number | 1940007 |
Pages | 1-13 |
DOI | https://doi.org/10.1142/s0219477519400078 |
Keywords | Ion channel; anomalous mole fraction effect; NaChBac; kinetic theory |
Public URL | https://nottingham-repository.worktribe.com/output/2507228 |
Publisher URL | https://www.worldscientific.com/doi/abs/10.1142/S0219477519400078 |
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Theory and Experiments on Multi-Ion Permeation and Selectivity in the NaChBac Ion Channel
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Publisher Licence URL
https://creativecommons.org/licenses/by/4.0/
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