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Theory and Experiments on Multi-Ion Permeation and Selectivity in the NaChBac Ion Channel

Gibby, W. A. T.; Barabash, M. L.; Guardiani, C.; Luchinsky, D. G.; Fedorenko, O. A.; Roberts, S. K.; McClintock, P. V. E.

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Authors

W. A. T. Gibby

M. L. Barabash

C. Guardiani

D. G. Luchinsky

O. A. Fedorenko

S. K. Roberts

P. V. E. McClintock



Abstract

The highly selective permeation of ions through biological ion channels is an unsolved problem of noise and fluctuations. In this paper, we motivate and introduce a non-equilibrium and self-consistent multi-species kinetic model, with the express aims of comparing with experimental recordings of current versus voltage and concentration and extracting important permeation parameters. For self-consistency, the behavior of the model at the two-state, i.e., selective limit in linear response, must agree with recent results derived from an equilibrium statistical theory. The kinetic model provides a good fit to data, including the key result of an anomalous mole fraction effect.

Citation

Gibby, W. A. T., Barabash, M. L., Guardiani, C., Luchinsky, D. G., Fedorenko, O. A., Roberts, S. K., & McClintock, P. V. E. (2019). Theory and Experiments on Multi-Ion Permeation and Selectivity in the NaChBac Ion Channel. Fluctuation and Noise Letters, 18(02), 1-13. https://doi.org/10.1142/s0219477519400078

Journal Article Type Article
Acceptance Date Feb 7, 2019
Online Publication Date May 29, 2019
Publication Date 2019-06
Deposit Date Aug 27, 2019
Publicly Available Date Mar 28, 2024
Journal Fluctuation and Noise Letters
Print ISSN 0219-4775
Electronic ISSN 1793-6780
Publisher World Scientific
Peer Reviewed Peer Reviewed
Volume 18
Issue 02
Article Number 1940007
Pages 1-13
DOI https://doi.org/10.1142/s0219477519400078
Keywords Ion channel; anomalous mole fraction effect; NaChBac; kinetic theory
Public URL https://nottingham-repository.worktribe.com/output/2507228
Publisher URL https://www.worldscientific.com/doi/abs/10.1142/S0219477519400078

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