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CDC20 expression in oestrogen receptor positive breast cancer predicts poor prognosis and lack of response to endocrine therapy

Alfarsi, Lutfi; Ansari, Rokaya El; Craze, Madeleine L.; Toss, Michael S.; Masisi, Brendah; Ellis, Ian O.; Rakha, Emad A.; Green, Andrew R.

Authors

Lutfi Alfarsi

Rokaya El Ansari

Madeleine L. Craze

Brendah Masisi

Emad A. Rakha

Andrew R. Green andrew.green@nohngham.ac.uk



Abstract

Purpose
Endocrine therapy is the standard treatment for oestrogen receptor positive (ER+) breast cancer. Despite its efficacy, around half of patients will develop resistance to this treatment and eventually relapse. Identification of effective and reliable biomarkers to predict the efficacy of endocrine therapy is of crucial importance in the management of ER+ breast cancer. Emerging evidence has revealed that the cell division regulator CDC20 exhibits an oncogenic function and plays important roles in tumourigenesis and progression of solid tumours. In this study, we investigated the prognostic and predictive role of CDC20 in early ER+ breast cancer patients.

Methods
The biological and clinical impact of CDC20 expression was assessed in large clinical annotated cohort of ER+ breast cancer with long-term follow-up at the mRNA level, using METABRIC and KM-Plotter datasets, and the protein level using immunohistochemistry on patients presenting at Nottingham. CDC20 expression was correlated with clinico-pathological parameters, molecular subtypes, clinical outcome and efficacy of endocrine therapy.

Results
High CDC20 mRNA expression was associated with poor clinico-pathological parameters including large tumour size and high tumour grade (P 

Journal Article Type Article
Publication Date 2019-12
Journal Breast Cancer Research and Treatment
Print ISSN 0167-6806
Electronic ISSN 1573-7217
Publisher Springer Verlag
Peer Reviewed Peer Reviewed
Volume 178
Issue 3
Pages 535-544
APA6 Citation Alfarsi, L., Ansari, R. E., Craze, M. L., Toss, M. S., Masisi, B., Ellis, I. O., …Green, A. R. (2019). CDC20 expression in oestrogen receptor positive breast cancer predicts poor prognosis and lack of response to endocrine therapy. Breast Cancer Research and Treatment, 178(3), 535-544. https://doi.org/10.1007/s10549-019-05420-8
DOI https://doi.org/10.1007/s10549-019-05420-8
Keywords CDC20; breast cancer; ER; endocrine resistance; predictive biomarker
Publisher URL https://link.springer.com/article/10.1007/s10549-019-05420-8
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