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Androgen Receptor Status Alone Not a Useful Prognostic Marker in Triple-Negative Breast Cancer

Bhattarai, Shristi; Klimov, Sergey; Mittal, Karuna; Krishnamurti, Uma; Li, Bill; Oprea-Ilies, Gabriela; Wetherilt, Ceyda Sonmez; Riaz, Ansa; Aleskandarany, Mohammad A.; Green, Andrew R.; Ellis, Ian O.; Cantuaria, Guilherme; Gupta, Meenakshi; Manne, Upender; Agboola, Johnson; Baskovich, Brett; Rakha, Emad; Rida, Padmashree; Aneja, Ritu

Authors

Shristi Bhattarai

Sergey Klimov

Karuna Mittal

Uma Krishnamurti

Bill Li

Gabriela Oprea-Ilies

Ceyda Sonmez Wetherilt

Ansa Riaz

Andrew R. Green

Guilherme Cantuaria

Meenakshi Gupta

Upender Manne

Johnson Agboola

Brett Baskovich

Emad Rakha

Padmashree Rida

Ritu Aneja



Abstract

Background: Androgen Receptor (AR) has emerged as a potential therapeutic target for AR-positive triple-negative breast cancer (TNBC). However, conflicting reports regarding AR’s prognostic role in TNBC are putting its usefulness in question. Some studies conclude that AR positivity indicates a good prognosis in TNBC whereas others suggest the opposite, and some show that AR status has no significant bearing on the patients’ prognosis. Methods: We evaluated the prognostic value of AR in resected primary tumors from TNBC patients from six international cohorts {US (n=420), UK (n=239), Norway (n=104), Ireland (n=222), Nigeria (n=180), and India (n=242); total n=1407}. All TNBC samples were stained with the same anti-AR antibody using the same immunohistochemistry protocol, and samples with ≥1% of AR-positive nuclei were deemed AR-positive TNBCs. Results: AR status shows population-specific patterns of association with patients’ overall survival after controlling for age, grade, population, and chemotherapy. We found AR-positive status to be a marker of good prognosis in US and Nigerian cohorts, a marker of poor prognosis in Norway, Ireland and Indian cohorts, and neutral in UK cohort. Conclusion: AR status, on its own, is not a reliable prognostic marker. More research to investigate molecular subtype composition among the different cohorts is warranted.

Journal Article Type Article
Publisher MDPI
Peer Reviewed Peer Reviewed
APA6 Citation Bhattarai, S., Klimov, S., Mittal, K., Krishnamurti, U., Li, B., Oprea-Ilies, G., …Aneja, R. (in press). Androgen Receptor Status Alone Not a Useful Prognostic Marker in Triple-Negative Breast Cancer. Cancers,