Skip to main content

Research Repository

Advanced Search

Cross-sectional study of reversible airway obstruction in LAM: better evidence is needed for bronchodilator and inhaled steroid use

Johnson, Jan; Johnson, Simon R

Authors

Jan Johnson

SIMON JOHNSON simon.johnson@nottingham.ac.uk
Professor of Respiratory Medicine



Abstract

Lymphangioleiomyomatosis can be associated with reversible airflow obstruction and although no guidelines around reversibility testing or inhaled therapy exist, many patients receive bronchodilators and inhaled corticosteroids. To better identify those who may benefit, we examined bronchodilator reversibility and inhaled therapy in a national cohort of 213 subjects. 20% of those tested had airway reversibility by standard criteria. 55% of patients used 13 different combinations of bronchodilators and inhaled corticosteroids. Increasing inhaler classes were associated with reversibility and more rapid FEV1 decline. Reversibility testing should be performed in all patients and inhaled therapy should be formally studied.

Citation

Johnson, J., & Johnson, S. R. (2019). Cross-sectional study of reversible airway obstruction in LAM: better evidence is needed for bronchodilator and inhaled steroid use. Thorax, 74(10), 999-1002. https://doi.org/10.1136/thoraxjnl-2019-213338

Journal Article Type Article
Acceptance Date Jul 5, 2019
Online Publication Date Jul 30, 2019
Publication Date 2019-10
Deposit Date Aug 7, 2019
Publicly Available Date Mar 29, 2024
Journal Thorax
Print ISSN 0040-6376
Electronic ISSN 1468-3296
Publisher BMJ Publishing Group
Peer Reviewed Peer Reviewed
Volume 74
Issue 10
Pages 999-1002
DOI https://doi.org/10.1136/thoraxjnl-2019-213338
Keywords Pulmonary and Respiratory Medicine
Public URL https://nottingham-repository.worktribe.com/output/2402633
Publisher URL https://thorax.bmj.com/content/early/2019/07/30/thoraxjnl-2019-213338
Additional Information This article has been accepted for publication in [Journal, Year]following peer review, and the Version of Record can be accessed online at http://dx.doi.org/10.1136/thoraxjnl-2019-213338.
© Authors (or their employer(s)) 2019. No commercial re-use. See rights and permissions. Published by BMJ.

Files




You might also like



Downloadable Citations