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Δccr5 Genotype Is Associated with Mild Form of Nephropathia Epidemica

Kletenkov, Konstantin; Martynova, Ekaterina; Davidyuk, Yuriy; Kabwe, Emmanuel; Shamsutdinov, Anton; Garanina, Ekaterina; Shakirova, Venera; Khaertynova, Ilsiyar; Anokhin, Vladimir; Tarlinton, Rachael; Rizvanov, Albert; Khaiboullina, Svetlana; Morzunov, Sergey

Authors

Konstantin Kletenkov

Ekaterina Martynova

Yuriy Davidyuk

Emmanuel Kabwe

Anton Shamsutdinov

Ekaterina Garanina

Venera Shakirova

Ilsiyar Khaertynova

Vladimir Anokhin

Rachael Tarlinton

Albert Rizvanov

Svetlana Khaiboullina

Sergey Morzunov

Abstract

Nephropathia Epidemica (NE), a mild form of hemorrhagic fever with renal syndrome (HFRS) and linked to hantavirus infection, is endemic in the Republic of Tatarstan. Several genetic markers of HFRS severity have been identified previously, including human leukocyte antigen (HLA) complexes and nucleotide polymorphism in the tumor necrosis factor alpha (TNFα) gene. Still, our understanding of the genetic markers of NE severity remains incomplete. The frequency of the C–C chemokine receptor type 5 (CCR5) gene wild type and gene with 32-base-pair deletion (Δ32CCR5) genotypes in 98 NE samples and 592 controls was analyzed using PCR. Along with the serum levels of 94 analytes, a lack of differences in the CCR5 genotype distribution between NE cases and the general population suggests that the CCR5 genotype does not affect susceptibility to hantavirus infection. However, in NE cases, significant variation in the serum levels of the host matrix metalloproteases between functional CCR5 homozygous and Δ32CCR5 heterozygous patients was detected. Also, the oliguric phase was longer, while thrombocyte counts were lower in functional CCR5 homozygous as compared to heterozygous NE cases. Our data, for the first time, presents the potential role of the CCR5 receptor genotype in NE pathogenesis. Our data suggests that NE pathogenesis in functional CCR5 homozygous and heterozygous NE patients differs, where homozygous cases may have more disintegration of the extracellular matrix and potentially more severe disease.

Journal Article Type Article
Publication Date Jul 23, 2019
Journal Viruses
Electronic ISSN 1999-4915
Publisher MDPI
Peer Reviewed Peer Reviewed
Volume 11
Issue 7
Article Number 675
Institution Citation Kletenkov, K., Martynova, E., Davidyuk, Y., Kabwe, E., Shamsutdinov, A., Garanina, E., …Morzunov, S. (2019). Δccr5 Genotype Is Associated with Mild Form of Nephropathia Epidemica. Viruses, 11(7), doi:10.3390/v11070675
DOI https://doi.org/10.3390/v11070675
Keywords Virology; Infectious Diseases
Publisher URL https://www.mdpi.com/1999-4915/11/7/675

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